kidney disease: A disease involving the kidney.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
3853 |
4. Check minimum number of eventsNone |
3853 |
5. Include endpoints |
4483 |
6. Filter based on genotype QC (FinnGen only) |
4301 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2
Other disorders of kidney and ureter
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 33497 | 15927 | 17200 |
| Only index persons | 27328 | 13369 | 13959 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.47 | 0.46 | 0.48 |
| Only index persons | 0.51 | 0.49 | 0.53 |
| Median age at first event (years) | |||
| Whole population | 60.77 | 58.84 | 62.51 |
| Only index persons | 59.27 | 56.82 | 61.62 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 4301 | 1988 | 2313 |
| Unadjusted period prevalence (%) | 0.99 | 0.78 | 1.16 |
| Median age at first event (years) | 59.60 | 54.55 | 63.94 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint N14_KIDUROTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| N14_KIDUROTH | 1.722 [1.55, 1.91] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.101 |
During the follow-up period (1.1.1998 — 31.12.2019), 2199 out of 9205 females with N14_KIDUROTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| N14_KIDUROTH | 1.645 [1.48, 1.83] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.056 |
During the follow-up period (1.1.1998 — 31.12.2019), 3019 out of 10504 males with N14_KIDUROTH died.
Mortality risk
Mortality risk for people of age
years, who have N14_KIDUROTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.176% | 0.319% |
| 5 | 0.913% | 2.114% |
| 10 | 2.31% | 5.413% |
| 15 | 4.537% | 10.031% |
| 20 | 7.977% | 17.194% |
Relationships between endpoints
↥Index endpoint: N14_KIDUROTH – Other disorders of kidney and ureter
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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