urinary system disease: A disease involving the renal system. [database_cross_reference: MONDO:DesignPattern]
Disorders resulting from impaired renal tubular function
DOID EFO Endpoint Browser PheWeb
N14_DISIMPAIRRENTUB
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1112 |
4. Check minimum number of eventsNone |
1112 |
5. Include endpointsNone |
1112 |
6. Filter based on genotype QC (FinnGen only) |
1055 |
Control definitions (FinnGen only)
Control exclude
N14_KIDUROTH
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
N25-N29
Name in latin
Morbositates ex dysfunctione tubulari renali
Similar endpoints
↥List of similar endpoints to
Disorders resulting from impaired renal tubular function
based on the number of shared cases.
Similar with more cases:
- Other disorders of kidney and ureter
- Genitourinary diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 5703 | 2664 | 3014 |
| Only index persons | 5111 | 2393 | 2718 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.08 | 0.08 | 0.08 |
| Only index persons | 0.10 | 0.09 | 0.10 |
| Median age at first event (years) | |||
| Whole population | 62.46 | 58.89 | 65.58 |
| Only index persons | 62.48 | 58.49 | 65.99 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1055 | 465 | 590 |
| Unadjusted period prevalence (%) | 0.25 | 0.18 | 0.30 |
| Median age at first event (years) | 60.05 | 56.38 | 62.95 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint N14_DISIMPAIRRENTUB and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| N14_DISIMPAIRRENTUB | 3.393 [2.82, 4.08] | < 0.001 |
| Birth year | 1.0 [0.99, 1.01] | 0.937 |
During the follow-up period (1.1.1998 — 31.12.2019), 646 out of 2093 females with N14_DISIMPAIRRENTUB died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| N14_DISIMPAIRRENTUB | 3.487 [2.81, 4.33] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 949 out of 2371 males with N14_DISIMPAIRRENTUB died.
Mortality risk
Mortality risk for people of age
years, who have N14_DISIMPAIRRENTUB.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.264% | 0.601% |
| 5 | 1.973% | 4.092% |
| 10 | 5.354% | 9.653% |
| 15 | 10.593% | 17.338% |
| 20 | 18.425% | 27.563% |
Relationships between endpoints
↥Index endpoint: N14_DISIMPAIRRENTUB – Disorders resulting from impaired renal tubular function
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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