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Unspecified contracted kidney

DOID EFO Endpoint Browser PheWeb

N14_UNSPECKIDCONTR

nephrosclerosis: Hardening of the walls of the small arteries and arterioles (small arteries that convey blood from arteries to the even smaller capillaries) of the kidney. This condition is caused by hypertension (high blood pressure)

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — N26
  • Hospital discharge: ICD-9 — 587
  • Hospital discharge: ICD-8 — 584
  • Cause of death: ICD-10 — N26
  • Cause of death: ICD-9 — 587
  • Cause of death: ICD-8 — 584

2 out of 7 registries used, show all original rules.

180

4. Check minimum number of events

None

180

5. Include endpoints

None

180

6. Filter based on genotype QC (FinnGen only)

171

Control definitions (FinnGen only)

Control exclude N14_KIDUROTH

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 N25-N29
Name in latin Ren contractus non specificatus

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2426 1203 1167
Only index persons 1486 779 707
Unadjusted period prevalence (%)
Whole population 0.03 0.03 0.03
Only index persons 0.03 0.03 0.03
Median age at first event (years)
Whole population 65.34 65.36 65.15
Only index persons 61.79 61.91 61.66

-FinnGen-

Key figures

All Female Male
Number of individuals 171 76 95
Unadjusted period prevalence (%) 0.04 0.03 0.05
Median age at first event (years) 56.13 54.77 57.22

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint N14_UNSPECKIDCONTR and mortality.

Females

Parameter HR [95% CI] p-value
N14_UNSPECKIDCONTR 2.593 [2.02, 3.33] < 0.001
Birth year 0.997 [0.99, 1.01] 0.521

During the follow-up period (1.1.1998 — 31.12.2019), 246 out of 605 females with N14_UNSPECKIDCONTR died.

Males

Parameter HR [95% CI] p-value
N14_UNSPECKIDCONTR 2.537 [1.95, 3.3] < 0.001
Birth year 0.989 [0.98, 1.0] 0.023

During the follow-up period (1.1.1998 — 31.12.2019), 233 out of 572 males with N14_UNSPECKIDCONTR died.

Mortality risk

Mortality risk for people of age

years, who have N14_UNSPECKIDCONTR.

N-year risk Females Males
1 0.242% 0.652%
5 1.628% 3.302%
10 4.228% 8.142%
15 7.901% 14.549%
20 13.33% 24.081%

Relationships between endpoints

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Index endpoint: N14_UNSPECKIDCONTR – Unspecified contracted kidney

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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