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Cyst of kidney

DOID EFO Endpoint Browser PheWeb

N14_CYSTKID

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — N28.1
  • Hospital discharge: ICD-9 — 5932
  • Hospital discharge: ICD-8 — 5932
  • Hospital discharge: excluded ICD-8 — 59322
  • Cause of death: ICD-10 — N28.1
  • Cause of death: ICD-9 — 5932
  • Cause of death: ICD-8 — 5932
  • Cause of death: excluded ICD-8 — 59322

2 out of 7 registries used, show all original rules.

2197

4. Check minimum number of events

None

2197

5. Include endpoints

None

2197

6. Filter based on genotype QC (FinnGen only)

2110

Control definitions (FinnGen only)

Control exclude N14_KIDUROTH

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 N28
Name in latin Cysta renis acquisita

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 16838 7771 8852
Only index persons 13632 6494 7138
Unadjusted period prevalence (%)
Whole population 0.24 0.22 0.25
Only index persons 0.26 0.24 0.27
Median age at first event (years)
Whole population 62.35 60.30 64.19
Only index persons 61.71 59.22 63.99

-FinnGen-

Key figures

All Female Male
Number of individuals 2110 926 1184
Unadjusted period prevalence (%) 0.49 0.36 0.59
Median age at first event (years) 62.31 57.96 65.72

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint N14_CYSTKID and mortality.

Females

Parameter HR [95% CI] p-value
N14_CYSTKID 0.991 [0.87, 1.12] 0.882
Birth year 0.992 [0.98, 1.0] 0.098

During the follow-up period (1.1.1998 — 31.12.2019), 665 out of 3819 females with N14_CYSTKID died.

Males

Parameter HR [95% CI] p-value
N14_CYSTKID 1.015 [0.9, 1.14] 0.803
Birth year 0.991 [0.98, 1.0] 0.063

During the follow-up period (1.1.1998 — 31.12.2019), 1049 out of 5032 males with N14_CYSTKID died.

Mortality risk

Mortality risk for people of age

years, who have N14_CYSTKID.

N-year risk Females Males
1 0.071% 0.189%
5 0.487% 1.29%
10 1.303% 3.222%
15 2.459% 6.147%
20 4.385% 10.785%

Relationships between endpoints

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Index endpoint: N14_CYSTKID – Cyst of kidney

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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