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Other specified disorders of kidney and ureter

DOID EFO Endpoint Browser PheWeb

N14_OTHETNASKIDUR

renal artery obstruction: Narrowing or occlusion of the renal artery or arteries. It is due usually to atherosclerosis; fibromuscular dysplasia; thrombosis; embolism, or external pressure. The reduced renal perfusion can lead to renovascular hypertension (hypertension, renovascular).

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — N28.0, N28.8, N28.9
  • Hospital discharge: ICD-9 — 593[0-1]|5938
  • Hospital discharge: ICD-8 — 59322
  • Hospital discharge: excluded ICD-8 — 5938B
  • Cause of death: ICD-10 — N28.0, N28.8, N28.9
  • Cause of death: ICD-9 — 593[0-1]|5938
  • Cause of death: ICD-8 — 59322
  • Cause of death: excluded ICD-8 — 5938B

2 out of 7 registries used, show all original rules.

1082

4. Check minimum number of events

None

1082

5. Include endpoints

None

1082

6. Filter based on genotype QC (FinnGen only)

1043

Control definitions (FinnGen only)

Control exclude N14_KIDUROTH

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 8686 4317 4295
Only index persons 7320 3755 3565
Unadjusted period prevalence (%)
Whole population 0.12 0.12 0.12
Only index persons 0.14 0.14 0.14
Median age at first event (years)
Whole population 54.35 54.58 53.91
Only index persons 51.26 51.89 50.59

-FinnGen-

Key figures

All Female Male
Number of individuals 1043 551 492
Unadjusted period prevalence (%) 0.23 0.22 0.25
Median age at first event (years) 54.34 48.33 61.07

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint N14_OTHETNASKIDUR and mortality.

Females

Parameter HR [95% CI] p-value
N14_OTHETNASKIDUR 1.911 [1.67, 2.19] < 0.001
Birth year 0.993 [0.98, 1.0] 0.084

During the follow-up period (1.1.1998 — 31.12.2019), 676 out of 2827 females with N14_OTHETNASKIDUR died.

Males

Parameter HR [95% CI] p-value
N14_OTHETNASKIDUR 1.936 [1.68, 2.23] < 0.001
Birth year 0.988 [0.98, 1.0] 0.014

During the follow-up period (1.1.1998 — 31.12.2019), 875 out of 2753 males with N14_OTHETNASKIDUR died.

Mortality risk

Mortality risk for people of age

years, who have N14_OTHETNASKIDUR.

N-year risk Females Males
1 0.198% 0.403%
5 1.025% 2.422%
10 2.618% 5.818%
15 4.757% 10.597%
20 8.364% 17.894%

Relationships between endpoints

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Index endpoint: N14_OTHETNASKIDUR – Other specified disorders of kidney and ureter

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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