No definition available.
Soft tissue disorders related to use, overuse and pressure
EFO MESH Endpoint Browser PheWeb
M13_SOFTOVERUSE
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
10521 |
4. Check minimum number of eventsNone |
10521 |
5. Include endpoints |
11105 |
6. Filter based on genotype QC (FinnGen only) |
10730 |
Control definitions (FinnGen only)
Control exclude
M13_SOFTTISSUE
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M70-M79
Name in latin
Morbositates textus mollis ad usum, abusum et/sive pressionem pertinentes
Similar endpoints
↥List of similar endpoints to
Soft tissue disorders related to use, overuse and pressure
based on the number of shared cases.
Similar with more cases:
- Soft tissue disorders
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 81252 | 41020 | 39896 |
| Only index persons | 76692 | 39389 | 37303 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.14 | 1.17 | 1.11 |
| Only index persons | 1.44 | 1.45 | 1.42 |
| Median age at first event (years) | |||
| Whole population | 54.57 | 58.16 | 50.87 |
| Only index persons | 54.11 | 57.76 | 50.25 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 10730 | 6244 | 4486 |
| Unadjusted period prevalence (%) | 2.37 | 2.45 | 2.25 |
| Median age at first event (years) | 56.14 | 56.62 | 55.47 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint M13_SOFTOVERUSE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_SOFTOVERUSE | 1.099 [1.0, 1.21] | 0.049 |
| Birth year | 0.995 [0.99, 1.0] | 0.188 |
During the follow-up period (1.1.1998 — 31.12.2019), 4657 out of 32082 females with M13_SOFTOVERUSE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_SOFTOVERUSE | 1.354 [1.23, 1.49] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.012 |
During the follow-up period (1.1.1998 — 31.12.2019), 4823 out of 29525 males with M13_SOFTOVERUSE died.
Mortality risk
Mortality risk for people of age
years, who have M13_SOFTOVERUSE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.123% | 0.297% |
| 5 | 0.684% | 1.546% |
| 10 | 1.722% | 4.1% |
| 15 | 3.293% | 7.919% |
| 20 | 5.791% | 13.128% |
Relationships between endpoints
↥Index endpoint: M13_SOFTOVERUSE – Soft tissue disorders related to use, overuse and pressure
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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