This is a non-core endpoint: only basic statistics are computed.
See these related core endpoints for full statistics:
Calcinosis cutis
L12_CALCINOSISCUTIS
connective tissue disease: A disorder characterized by abnormalities in one or more of the elements of the connective tissues, typically associated with genetic defects.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
50 |
4. Check minimum number of eventsNone |
50 |
5. Include endpointsNone |
50 |
6. Filter based on genotype QC (FinnGen only) |
48 |
Control definitions (FinnGen only)
Control exclude
L12_OTHERSKINSUBCUTIS
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L94
Name in latin
Calcinosis cutis
Similar endpoints
↥List of similar endpoints to
Calcinosis cutis
based on the number of shared cases.
Similar with more cases:
- Other localized connective tissue disorders
- Other disorders of skin and subcutaneous tissue
- Diseases of the skin and subcutaneous tissue
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 288 | 172 | 115 |
| Only index persons | 267 | 159 | 108 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.00 | 0.00 | 0.00 |
| Only index persons | 0.01 | 0.01 | 0.00 |
| Median age at first event (years) | |||
| Whole population | 64.69 | 68.70 | 58.79 |
| Only index persons | 64.73 | 68.91 | 58.58 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 48 | 29 | 19 |
| Unadjusted period prevalence (%) | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | 62.94 | 65.09 | 59.67 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
No data
-FinnGen-
Cumulative Incidence Function
Not a core endpoint, no data to show.
Mortality – FinRegistry
↥Association
Association between endpoint L12_CALCINOSISCUTIS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_CALCINOSISCUTIS | 4.812 [1.96, 11.82] | < 0.001 |
| Birth year | 0.998 [0.99, 1.01] | 0.559 |
During the follow-up period (1.1.1998 — 31.12.2019), 56 out of 132 females with L12_CALCINOSISCUTIS died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have L12_CALCINOSISCUTIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.542% | No data |
| 5 | 3.161% | No data |
| 10 | 7.911% | No data |
| 15 | 14.384% | No data |
| 20 | 23.902% | No data |
Relationships between endpoints
↥Index endpoint: L12_CALCINOSISCUTIS – Calcinosis cutis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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