hypersensitivity vasculitis: Disorder characterized by a vasculitic syndrome associated with exposure to an antigen such as a drug, infectious agent, or other foreign or endogenous substance. Its pathophysiology includes immune complex deposition and a wide range of skin lesions. Hypersensitivity or allergy is present in some but not all cases.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
754 |
4. Check minimum number of eventsNone |
754 |
5. Include endpointsNone |
754 |
6. Filter based on genotype QC (FinnGen only) |
724 |
Control definitions (FinnGen only)
Control exclude
L12_OTHERSKINSUBCUTIS
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Other and unspecified vasculitis limited to skin
based on the number of shared cases.
Similar with more cases:
- Vasculitis limited to skin, not elsewhere classified
- Other disorders of skin and subcutaneous tissue
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 5748 | 3379 | 2331 |
| Only index persons | 5105 | 3007 | 2098 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.08 | 0.10 | 0.07 |
| Only index persons | 0.10 | 0.11 | 0.08 |
| Median age at first event (years) | |||
| Whole population | 64.72 | 66.92 | 61.51 |
| Only index persons | 63.26 | 65.05 | 60.70 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 724 | 422 | 302 |
| Unadjusted period prevalence (%) | 0.16 | 0.17 | 0.15 |
| Median age at first event (years) | 61.50 | 59.77 | 63.93 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint L12_VASCULITISNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_VASCULITISNAS | 2.781 [2.39, 3.24] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.216 |
During the follow-up period (1.1.1998 — 31.12.2019), 1063 out of 2856 females with L12_VASCULITISNAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_VASCULITISNAS | 2.679 [2.22, 3.24] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.032 |
During the follow-up period (1.1.1998 — 31.12.2019), 699 out of 1962 males with L12_VASCULITISNAS died.
Mortality risk
Mortality risk for people of age
years, who have L12_VASCULITISNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.272% | 0.627% |
| 5 | 1.768% | 3.441% |
| 10 | 4.143% | 8.225% |
| 15 | 8.192% | 15.612% |
| 20 | 13.626% | 25.911% |
Relationships between endpoints
↥Index endpoint: L12_VASCULITISNAS – Other and unspecified vasculitis limited to skin
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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