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Personality disorders

Endpoint Browser PheWeb

KRA_PSY_PERSON_EXMORE

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

None

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2. Check conditions

None

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — F60, F61
  • Hospital discharge: ICD-9 — 31[0|2|4]|315A|31[6-8]
  • Hospital discharge: ICD-8 — 30100|301[2-9]
  • Cause of death: ICD-10 — F60, F61
  • Cause of death: ICD-9 — 31[0|2|4]|315A|31[6-8]
  • Cause of death: ICD-8 — 30100|301[2-9]

2 out of 7 registries used, show all original rules.

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4. Check minimum number of events

None

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5. Include endpoints

None

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6. Filter based on genotype QC (FinnGen only)

None

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Control definitions (FinnGen only)

Control exclude KRA_PSY_ANYMENTAL

Extra metadata

First used in FinnGen datafreeze DF2

Case counts by codes

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FinnGen case counts by registry codes:

No upset plot: script not run.

No upset table: script not run.

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 118192 61352 55922
Only index persons 104272 56926 47346
Unadjusted period prevalence (%)
Whole population 1.66 1.76 1.56
Only index persons 1.96 2.09 1.81
Median age at first event (years)
Whole population 31.56 32.06 30.92
Only index persons 30.95 31.47 30.32

-FinnGen-

Key figures

All Female Male
Number of individuals 11914 7600 4314
Unadjusted period prevalence (%) 2.69 2.98 2.17
Median age at first event (years) 33.02 32.52 33.90

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint KRA_PSY_PERSON_EXMORE and mortality.

Females

Parameter HR [95% CI] p-value
KRA_PSY_PERSON_EXMORE 2.976 [2.71, 3.27] < 0.001
Birth year 0.991 [0.98, 1.0] 0.038

During the follow-up period (1.1.1998 — 31.12.2019), 3469 out of 43099 females with KRA_PSY_PERSON_EXMORE died.

Males

Parameter HR [95% CI] p-value
KRA_PSY_PERSON_EXMORE 3.456 [3.19, 3.75] < 0.001
Birth year 0.985 [0.98, 0.99] 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 4951 out of 31178 males with KRA_PSY_PERSON_EXMORE died.

Mortality risk

Mortality risk for people of age

years, who have KRA_PSY_PERSON_EXMORE.

N-year risk Females Males
1 0.219% 0.631%
5 1.401% 3.727%
10 3.86% 8.675%
15 7.525% 16.361%
20 12.905% 26.29%

Relationships between endpoints

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Index endpoint: KRA_PSY_PERSON_EXMORE – Personality disorders

GWS hits: 2

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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