dumping syndrome: Gastrointestinal symptoms resulting from an absent or nonfunctioning pylorus.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
19517 |
4. Check minimum number of eventsNone |
19517 |
5. Include endpoints |
20554 |
6. Filter based on genotype QC (FinnGen only) |
19834 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2
Other diseases of the digestive system
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 213210 | 101910 | 109178 |
| Only index persons | 168685 | 82909 | 85776 |
| Unadjusted period prevalence (%) | |||
| Whole population | 2.98 | 2.92 | 3.05 |
| Only index persons | 3.16 | 3.05 | 3.27 |
| Median age at first event (years) | |||
| Whole population | 63.29 | 65.41 | 61.20 |
| Only index persons | 60.72 | 61.91 | 59.58 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 19834 | 9459 | 10375 |
| Unadjusted period prevalence (%) | 4.50 | 3.71 | 5.21 |
| Median age at first event (years) | 60.48 | 55.46 | 65.05 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint K11_OTHDIG and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_OTHDIG | 2.017 [1.84, 2.22] | < 0.001 |
| Birth year | 0.993 [0.99, 1.0] | 0.058 |
During the follow-up period (1.1.1998 — 31.12.2019), 26481 out of 76257 females with K11_OTHDIG died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_OTHDIG | 2.58 [2.33, 2.86] | < 0.001 |
| Birth year | 0.984 [0.98, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 32056 out of 79617 males with K11_OTHDIG died.
Mortality risk
Mortality risk for people of age
years, who have K11_OTHDIG.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.153% | 0.414% |
| 5 | 0.951% | 2.423% |
| 10 | 2.477% | 6.114% |
| 15 | 5.118% | 10.966% |
| 20 | 8.6% | 18.372% |
Relationships between endpoints
↥Index endpoint: K11_OTHDIG – Other diseases of the digestive system
GWS hits: 8
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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