celiac disease: An autoimmune genetic disorder with an unknown pattern of inheritance that primarily affects the digestive tract. It is caused by intolerance to dietary gluten. Consumption of gluten protein triggers an immune response which damages small intestinal villi and prevents adequate absorption of nutrients. Clinical signs include abdominal cramping, diarrhea or constipation and weight loss. If untreated, the clinical course may progress to malnutrition, anemia, osteoporosis and an increased risk of intestinal malignancies. However, the prognosis is favorable with successful avoidance of gluten in the diet.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
4690 |
4. Check minimum number of eventsNone |
4690 |
5. Include endpointsNone |
4690 |
6. Filter based on genotype QC (FinnGen only) |
4568 |
Control definitions (FinnGen only)
Control exclude
K11_OTHDIG
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
K90
Name in latin
Coeliacia
Similar endpoints
↥List of similar endpoints to
Coeliac disease
based on the number of shared cases.
Similar with more cases:
- Other diseases of the digestive system
- Autoimmune diseases
- Used for control exclusion in common control thyroid runs
- Gastrointestinal diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 41288 | 26294 | 14867 |
| Only index persons | 37624 | 24175 | 13449 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.63 | 0.75 | 0.42 |
| Only index persons | 0.75 | 0.89 | 0.51 |
| Median age at first event (years) | |||
| Whole population | 43.74 | 42.38 | 46.02 |
| Only index persons | 44.13 | 43.05 | 46.07 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 4568 | 3069 | 1499 |
| Unadjusted period prevalence (%) | 1.06 | 1.21 | 0.75 |
| Median age at first event (years) | 48.67 | 45.64 | 54.87 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint K11_COELIAC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_COELIAC | 1.175 [1.06, 1.3] | 0.002 |
| Birth year | 0.997 [0.99, 1.0] | 0.431 |
During the follow-up period (1.1.1998 — 31.12.2019), 2214 out of 22892 females with K11_COELIAC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_COELIAC | 1.249 [1.13, 1.38] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.008 |
During the follow-up period (1.1.1998 — 31.12.2019), 1834 out of 12791 males with K11_COELIAC died.
Mortality risk
Mortality risk for people of age
years, who have K11_COELIAC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.126% | 0.224% |
| 5 | 0.726% | 1.342% |
| 10 | 1.777% | 3.557% |
| 15 | 3.509% | 6.731% |
| 20 | 6.402% | 11.434% |
Relationships between endpoints
↥Index endpoint: K11_COELIAC – Coeliac disease
GWS hits: 23
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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