gastrointestinal disease: ['A disease that occurs in the gastrointestinal system, excluding the hepatobiliary system.']
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
13423 |
4. Check minimum number of eventsNone |
13423 |
5. Include endpointsNone |
13423 |
6. Filter based on genotype QC (FinnGen only) |
12913 |
Control definitions (FinnGen only)
Control exclude
K11_OTHDIG
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
K90-K93
Name in latin
Alii morbi systematis digestorii
Other diseases of the digestive system
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 142952 | 62002 | 79493 |
| Only index persons | 114605 | 50482 | 64123 |
| Unadjusted period prevalence (%) | |||
| Whole population | 2.02 | 1.78 | 2.22 |
| Only index persons | 2.19 | 1.86 | 2.45 |
| Median age at first event (years) | |||
| Whole population | 68.64 | 74.05 | 64.37 |
| Only index persons | 67.45 | 72.40 | 63.55 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 12913 | 5139 | 7774 |
| Unadjusted period prevalence (%) | 3.15 | 2.02 | 3.90 |
| Median age at first event (years) | 66.52 | 64.42 | 67.91 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint K11_OTHDISDIG and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_OTHDISDIG | 2.306 [2.09, 2.55] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.221 |
During the follow-up period (1.1.1998 — 31.12.2019), 23576 out of 49687 females with K11_OTHDISDIG died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_OTHDISDIG | 2.833 [2.54, 3.15] | < 0.001 |
| Birth year | 0.983 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 29570 out of 63929 males with K11_OTHDISDIG died.
Mortality risk
Mortality risk for people of age
years, who have K11_OTHDISDIG.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.174% | 0.48% |
| 5 | 1.203% | 2.613% |
| 10 | 3.199% | 6.513% |
| 15 | 5.946% | 11.893% |
| 20 | 10.278% | 19.902% |
Relationships between endpoints
↥Index endpoint: K11_OTHDISDIG – Other diseases of the digestive system
GWS hits: 3
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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