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Intestinal malabsorption

DOID EFO Endpoint Browser PheWeb

K11_MALABSORB

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — K90
  • Hospital discharge: ICD-9 — 579
  • Hospital discharge: ICD-8 — 269[1-2]
  • Hospital discharge: excluded ICD-10 — K90.0
  • Hospital discharge: excluded ICD-9 — 5790A|5793
  • Cause of death: ICD-10 — K90
  • Cause of death: ICD-9 — 579
  • Cause of death: ICD-8 — 269[1-2]
  • Cause of death: excluded ICD-10 — K90.0
  • Cause of death: excluded ICD-9 — 5790A|5793

2 out of 7 registries used, show all original rules.

1556

4. Check minimum number of events

None

1556

5. Include endpoints

None

1556

6. Filter based on genotype QC (FinnGen only)

1514

Control definitions (FinnGen only)

Control exclude K11_OTHDIG

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 K90-K93
Name in latin Malabsorptio intestinalis

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 11847 6237 5568
Only index persons 10703 5689 5014
Unadjusted period prevalence (%)
Whole population 0.17 0.18 0.16
Only index persons 0.20 0.21 0.19
Median age at first event (years)
Whole population 43.35 44.21 42.26
Only index persons 40.87 42.42 39.10

-FinnGen-

Key figures

All Female Male
Number of individuals 1514 911 603
Unadjusted period prevalence (%) 0.34 0.36 0.30
Median age at first event (years) 48.64 44.47 54.94

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint K11_MALABSORB and mortality.

Females

Parameter HR [95% CI] p-value
K11_MALABSORB 1.991 [1.74, 2.28] < 0.001
Birth year 0.995 [0.99, 1.0] 0.281

During the follow-up period (1.1.1998 — 31.12.2019), 744 out of 4077 females with K11_MALABSORB died.

Males

Parameter HR [95% CI] p-value
K11_MALABSORB 2.141 [1.85, 2.47] < 0.001
Birth year 0.992 [0.98, 1.0] 0.094

During the follow-up period (1.1.1998 — 31.12.2019), 842 out of 3277 males with K11_MALABSORB died.

Mortality risk

Mortality risk for people of age

years, who have K11_MALABSORB.

N-year risk Females Males
1 0.129% 0.445%
5 1.108% 2.958%
10 2.833% 6.885%
15 5.54% 13.216%
20 9.893% 22.331%

Relationships between endpoints

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Index endpoint: K11_MALABSORB – Intestinal malabsorption

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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