Crohn's disease: A gastrointestinal disorder characterized by chronic inflammation involving all layers of the intestinal wall, noncaseating granulomas affecting the intestinal wall and regional lymph nodes, and transmural fibrosis. Crohn disease most commonly involves the terminal ileum; the colon is the second most common site of involvement.
Crohn disease (strict definition, require KELA, min 2 HDR)
K11_CD_STRICT2
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditions
|
2449 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
2272 |
4. Check minimum number of eventsNone |
2272 |
5. Include endpointsNone |
2272 |
6. Filter based on genotype QC (FinnGen only) |
2186 |
Control definitions (FinnGen only)
Control conditions
not K11_KELACROHN
Extra metadata
Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF3
Parent code in ICD-10
K50-K52
Name in latin
Morbus Crohn
Similar endpoints
↥List of similar endpoints to
Crohn disease (strict definition, require KELA, min 2 HDR)
based on the number of shared cases.
Similar with more cases:
- Crohn disease (strict definition, require KELA)
- Crohn's disease patients in KELA-register (KELA code 209, or 208 with ICD K50)
- Crohn disease
- IBD patients in KELA-register
- Inflammatory bowel disease, strict (require KELA)
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 12555 | 6354 | 6153 |
| Only index persons | 12138 | 6175 | 5963 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.18 | 0.18 | 0.17 |
| Only index persons | 0.23 | 0.23 | 0.23 |
| Median age at first event (years) | |||
| Whole population | 35.44 | 35.86 | 34.99 |
| Only index persons | 35.17 | 35.59 | 34.74 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2186 | 1258 | 928 |
| Unadjusted period prevalence (%) | 0.48 | 0.49 | 0.47 |
| Median age at first event (years) | 38.23 | 37.14 | 39.72 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint K11_CD_STRICT2 and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_CD_STRICT2 | 1.165 [1.01, 1.34] | 0.033 |
| Birth year | 0.998 [0.99, 1.01] | 0.711 |
During the follow-up period (1.1.1998 — 31.12.2019), 291 out of 5295 females with K11_CD_STRICT2 died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_CD_STRICT2 | 1.13 [0.99, 1.29] | 0.074 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 374 out of 5115 males with K11_CD_STRICT2 died.
Mortality risk
Mortality risk for people of age
years, who have K11_CD_STRICT2.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.11% | 0.199% |
| 5 | 0.842% | 1.372% |
| 10 | 1.983% | 3.277% |
| 15 | 3.736% | 6.183% |
| 20 | 6.677% | 10.509% |
Relationships between endpoints
↥Index endpoint: K11_CD_STRICT2 – Crohn disease (strict definition, require KELA, min 2 HDR)
GWS hits: 9
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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