inflammatory bowel disease: A spectrum of small and large bowel inflammatory diseases of unknown etiology. It includes Crohn's disease, ulcerative colitis, and colitis of indeterminate type.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
10091 |
4. Check minimum number of eventsNone |
10091 |
5. Include endpointsNone |
10091 |
6. Filter based on genotype QC (FinnGen only) |
9759 |
Control definitions (FinnGen only)
Control exclude
K11_ENERCOLNONINF
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF3
Similar endpoints
↥List of similar endpoints to
IBD patients in KELA-register
based on the number of shared cases.
Similar with more cases:
- Inflammatory bowel disease, strict (require KELA)
- Inflammatory bowel disease
- Noninfective enteritis and colitis
- Autoimmune diseases related-to ILD
- Autoimmune diseases
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 64105 | 29608 | 34206 |
| Only index persons | 60335 | 28315 | 32020 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.90 | 0.85 | 0.96 |
| Only index persons | 1.14 | 1.04 | 1.22 |
| Median age at first event (years) | |||
| Whole population | 37.43 | 36.66 | 37.96 |
| Only index persons | 36.55 | 36.07 | 36.98 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 9759 | 5081 | 4678 |
| Unadjusted period prevalence (%) | 2.17 | 2.00 | 2.35 |
| Median age at first event (years) | 38.30 | 35.65 | 41.18 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint K11_KELAIBD and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_KELAIBD | 1.182 [1.05, 1.33] | 0.005 |
| Birth year | 0.987 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 1248 out of 20102 females with K11_KELAIBD died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_KELAIBD | 1.016 [0.92, 1.12] | 0.756 |
| Birth year | 0.99 [0.98, 1.0] | 0.053 |
During the follow-up period (1.1.1998 — 31.12.2019), 1842 out of 23160 males with K11_KELAIBD died.
Mortality risk
Mortality risk for people of age
years, who have K11_KELAIBD.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.066% | 0.24% |
| 5 | 0.49% | 1.366% |
| 10 | 1.328% | 3.195% |
| 15 | 2.437% | 6.092% |
| 20 | 4.375% | 10.619% |
Relationships between endpoints
↥Index endpoint: K11_KELAIBD – IBD patients in KELA-register
GWS hits: 68
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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