inflammatory bowel disease: A spectrum of small and large bowel inflammatory diseases of unknown etiology. It includes Crohn's disease, ulcerative colitis, and colitis of indeterminate type.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditions
|
10091 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
10091 |
6. Filter based on genotype QC (FinnGen only) |
9759 |
Control definitions (FinnGen only)
Control exclude
K11_IBD_STRICT_PSC
Control conditions
not K11_KELAIBD
Extra metadata
Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF9
Similar endpoints
↥List of similar endpoints to
Inflammatory bowel disease, strict (require KELA)
based on the number of shared cases.
Similar with more cases:
- IBD patients in KELA-register
- Inflammatory bowel disease
- Noninfective enteritis and colitis
- Autoimmune diseases related-to ILD
- Autoimmune diseases
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No data for upset plot.
No data for upset table.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 64105 | 29608 | 34206 |
| Only index persons | 60335 | 28315 | 32020 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.90 | 0.85 | 0.96 |
| Only index persons | 1.14 | 1.04 | 1.22 |
| Median age at first event (years) | |||
| Whole population | 36.15 | 35.44 | 36.65 |
| Only index persons | 35.35 | 34.89 | 35.77 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 9759 | 5081 | 4678 |
| Unadjusted period prevalence (%) | 2.17 | 2.00 | 2.35 |
| Median age at first event (years) | 36.90 | 34.40 | 39.62 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint K11_IBD_STRICT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_IBD_STRICT | 1.085 [0.97, 1.21] | 0.14 |
| Birth year | 0.998 [0.99, 1.01] | 0.612 |
During the follow-up period (1.1.1998 — 31.12.2019), 1175 out of 19933 females with K11_IBD_STRICT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_IBD_STRICT | 1.013 [0.91, 1.13] | 0.804 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 1725 out of 22941 males with K11_IBD_STRICT died.
Mortality risk
Mortality risk for people of age
years, who have K11_IBD_STRICT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.109% | 0.171% |
| 5 | 0.651% | 0.991% |
| 10 | 1.785% | 2.637% |
| 15 | 3.486% | 5.091% |
| 20 | 6.223% | 8.625% |
Relationships between endpoints
↥Index endpoint: K11_IBD_STRICT – Inflammatory bowel disease, strict (require KELA)
GWS hits: 67
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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