cerebrovascular disorder: A disorder resulting from inadequate blood flow in the vessels that supply the brain. Representative examples include cerebrovascular ischemia, cerebral embolism, and cerebral infarction.
Vascular syndromes of brain in cerebrovascular disorders
DOID EFO Endpoint Browser PheWeb
I9_VASCSYND
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
1484 |
4. Check minimum number of eventsNone |
1484 |
5. Include endpointsNone |
1484 |
6. Filter based on genotype QC (FinnGen only) |
1433 |
Control definitions (FinnGen only)
Control exclude
F5_DEMENTIA, G6_ALZHEIMER, G6_AD_WIDE
Extra metadata
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Vascular syndromes of brain in cerebrovascular disorders
based on the number of shared cases.
Similar with more cases:
- Vascular syndromes of brain in cerebrovascular disorders
- Other neurological diseases
- Episodal and paroxysmal disorders
- Neurological diseases
- Neurological diseases
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 16266 | 7420 | 8756 |
| Only index persons | 13791 | 6353 | 7438 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.23 | 0.21 | 0.24 |
| Only index persons | 0.26 | 0.23 | 0.28 |
| Median age at first event (years) | |||
| Whole population | 72.14 | 75.72 | 69.09 |
| Only index persons | 71.24 | 74.84 | 68.16 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1433 | 592 | 841 |
| Unadjusted period prevalence (%) | 0.34 | 0.23 | 0.42 |
| Median age at first event (years) | 68.38 | 66.67 | 69.58 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint I9_VASCSYND and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_VASCSYND | 1.763 [1.59, 1.95] | < 0.001 |
| Birth year | 0.997 [0.99, 1.0] | 0.426 |
During the follow-up period (1.1.1998 — 31.12.2019), 3004 out of 6262 females with I9_VASCSYND died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_VASCSYND | 1.723 [1.56, 1.91] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.061 |
During the follow-up period (1.1.1998 — 31.12.2019), 3452 out of 7567 males with I9_VASCSYND died.
Mortality risk
Mortality risk for people of age
years, who have I9_VASCSYND.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.223% | 0.306% |
| 5 | 1.094% | 2.122% |
| 10 | 2.811% | 5.601% |
| 15 | 5.449% | 10.96% |
| 20 | 9.249% | 18.455% |
Relationships between endpoints
↥Index endpoint: I9_VASCSYND – Vascular syndromes of brain in cerebrovascular disorders
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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