eye disease: A non-neoplastic or neoplastic disorder that affects the eye. Representative examples include conjunctivitis, glaucoma, cataract, conjunctival squamous cell carcinoma, uveal melanoma, and retinoblastoma. [NCIt:C26767]
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
19427 |
4. Check minimum number of eventsNone |
19427 |
5. Include endpoints |
19550 |
6. Filter based on genotype QC (FinnGen only) |
18951 |
Control definitions (FinnGen only)
Control exclude
H7_VITREOUS
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H43-H45
Name in latin
Morbositates corporis vitrei
Similar endpoints
↥List of similar endpoints to
Disorders of vitreous body
based on the number of shared cases.
Similar with more cases:
- Disorders of vitreous body and globe
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 127368 | 79793 | 47138 |
| Only index persons | 121972 | 77369 | 44603 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.92 | 2.29 | 1.32 |
| Only index persons | 2.43 | 2.84 | 1.70 |
| Median age at first event (years) | |||
| Whole population | 63.96 | 63.44 | 64.88 |
| Only index persons | 63.84 | 63.30 | 64.77 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 18951 | 11982 | 6969 |
| Unadjusted period prevalence (%) | 4.26 | 4.71 | 3.50 |
| Median age at first event (years) | 63.50 | 62.33 | 65.52 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint H7_VITRBODYGLOBE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_VITRBODYGLOBE | 0.937 [0.86, 1.02] | 0.152 |
| Birth year | 0.995 [0.99, 1.0] | 0.198 |
During the follow-up period (1.1.1998 — 31.12.2019), 7860 out of 66146 females with H7_VITRBODYGLOBE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_VITRBODYGLOBE | 1.008 [0.92, 1.11] | 0.868 |
| Birth year | 0.987 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 7188 out of 38411 males with H7_VITRBODYGLOBE died.
Mortality risk
Mortality risk for people of age
years, who have H7_VITRBODYGLOBE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.09% | 0.178% |
| 5 | 0.561% | 1.071% |
| 10 | 1.298% | 2.785% |
| 15 | 2.644% | 5.137% |
| 20 | 4.601% | 9.052% |
Relationships between endpoints
↥Index endpoint: H7_VITRBODYGLOBE – Disorders of vitreous body
GWS hits: 3
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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