Crystalline deposits in vitreous body

H7_VITRCRYSTAL

eye disease: A non-neoplastic or neoplastic disorder that affects the eye. Representative examples include conjunctivitis, glaucoma, cataract, conjunctival squamous cell carcinoma, uveal melanoma, and retinoblastoma. [NCIt:C26767]

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 H43.2
  • Cause of death: ICD-10 H43.2

2 out of 7 registries used, show all original rules.

264

4. Check minimum number of events

None

264

5. Include endpoints

None

264

6. Filter based on genotype QC (FinnGen only)

253

Control definitions (FinnGen only)

Control exclude H7_VITREOUS

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 H43
Name in latin Depositiones crystallinae corporis vitrei

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1754 700 1049
Only index persons 1640 667 973
Unadjusted period prevalence (%)
Whole population 0.03 0.02 0.03
Only index persons 0.03 0.02 0.04
Median age at first event (years)
Whole population 71.12 69.89 71.95
Only index persons 70.79 69.70 71.54

-FinnGen-

Key figures

All Female Male
Number of individuals 253 98 155
Unadjusted period prevalence (%) 0.06 0.04 0.08
Median age at first event (years) 68.71 65.39 70.82

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

Association

Association between endpoint H7_VITRCRYSTAL and mortality.

Females

Parameter HR [95% CI] p-value
H7_VITRCRYSTAL 0.983 [0.8, 1.21] 0.868
Birth year 0.996 [0.99, 1.0] 0.342

During the follow-up period (1.1.1998 — 31.12.2019), 133 out of 603 females with H7_VITRCRYSTAL died.

Males

Parameter HR [95% CI] p-value
H7_VITRCRYSTAL 0.981 [0.8, 1.2] 0.852
Birth year 0.989 [0.98, 1.0] 0.021

During the follow-up period (1.1.1998 — 31.12.2019), 251 out of 834 males with H7_VITRCRYSTAL died.

Mortality risk

Mortality risk for people of age

years, who have H7_VITRCRYSTAL.

N-year risk Females Males
1 0.063% 0.173%
5 0.566% 1.147%
10 1.412% 2.925%
15 2.787% 5.421%
20 4.935% 9.54%

Relationships between endpoints

Index endpoint: H7_VITRCRYSTAL – Crystalline deposits in vitreous body

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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