eye disease: A non-neoplastic or neoplastic disorder that affects the eye. Representative examples include conjunctivitis, glaucoma, cataract, conjunctival squamous cell carcinoma, uveal melanoma, and retinoblastoma. [NCIt:C26767]
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
78 |
4. Check minimum number of eventsNone |
78 |
5. Include endpointsNone |
78 |
6. Filter based on genotype QC (FinnGen only) |
76 |
Control definitions (FinnGen only)
Control exclude
H7_VITREOUS
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H43
Name in latin
Prolapsus corporis vitrei
Similar endpoints
↥List of similar endpoints to
Vitreous prolapse
based on the number of shared cases.
Similar with more cases:
- Disorders of vitreous body
- Disorders of vitreous body and globe
- Diseases of the eye and adnexa
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 559 | 343 | 212 |
| Only index persons | 534 | 334 | 200 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 63.03 | 63.47 | 62.46 |
| Only index persons | 62.75 | 63.45 | 61.58 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 76 | 52 | 24 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.01 |
| Median age at first event (years) | 58.94 | 57.08 | 62.97 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint H7_VITRPROLAPSE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_VITRPROLAPSE | 1.037 [0.8, 1.35] | 0.788 |
| Birth year | 0.997 [0.99, 1.01] | 0.478 |
During the follow-up period (1.1.1998 — 31.12.2019), 59 out of 299 females with H7_VITRPROLAPSE died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have H7_VITRPROLAPSE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.133% | No data |
| 5 | 0.737% | No data |
| 10 | 1.708% | No data |
| 15 | 3.248% | No data |
| 20 | 5.587% | No data |
Relationships between endpoints
↥Index endpoint: H7_VITRPROLAPSE – Vitreous prolapse
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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