Other and unspecified disorders of vitreous body

H7_VITROTH

eye disease: A non-neoplastic or neoplastic disorder that affects the eye. Representative examples include conjunctivitis, glaucoma, cataract, conjunctival squamous cell carcinoma, uveal melanoma, and retinoblastoma. [NCIt:C26767]

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 H43.8, H43.9
  • Hospital discharge: ICD-9 3792A
  • Hospital discharge: ICD-8 37840
  • Cause of death: ICD-10 H43.8, H43.9
  • Cause of death: ICD-9 3792A
  • Cause of death: ICD-8 37840

2 out of 7 registries used, show all original rules.

15560

4. Check minimum number of events

None

15560

5. Include endpoints

None

15560

6. Filter based on genotype QC (FinnGen only)

15092

Control definitions (FinnGen only)

Control exclude H7_VITREOUS

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF6

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 98239 65258 32715
Only index persons 95799 64131 31668
Unadjusted period prevalence (%)
Whole population 1.55 1.87 0.91
Only index persons 1.98 2.36 1.21
Median age at first event (years)
Whole population 63.92 63.29 65.22
Only index persons 63.87 63.24 65.16

-FinnGen-

Key figures

All Female Male
Number of individuals 15092 10103 4989
Unadjusted period prevalence (%) 3.48 3.97 2.51
Median age at first event (years) 63.87 62.71 66.23

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint H7_VITROTH and mortality.

Females

Parameter HR [95% CI] p-value
H7_VITROTH 0.718 [0.65, 0.79] < 0.001
Birth year 0.996 [0.99, 1.0] 0.28

During the follow-up period (1.1.1998 — 31.12.2019), 4325 out of 53822 females with H7_VITROTH died.

Males

Parameter HR [95% CI] p-value
H7_VITROTH 0.703 [0.63, 0.78] < 0.001
Birth year 0.986 [0.98, 0.99] 0.002

During the follow-up period (1.1.1998 — 31.12.2019), 3287 out of 26151 males with H7_VITROTH died.

Mortality risk

Mortality risk for people of age

years, who have H7_VITROTH.

N-year risk Females Males
1 0.063% 0.154%
5 0.354% 0.828%
10 1.011% 2.072%
15 2.029% 3.901%
20 3.577% 6.741%

Relationships between endpoints

Index endpoint: H7_VITROTH – Other and unspecified disorders of vitreous body

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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