conjunctivitis: Inflammation of the conjunctiva of the eye. [ NCIT:P378 ]
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
37619 |
6. Filter based on genotype QC (FinnGen only) |
36160 |
Control definitions (FinnGen only)
Control exclude
H7_CONJUNCTIVA
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Conjunctivitis
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 372142 | 217372 | 153513 |
| Only index persons | 331205 | 198780 | 132425 |
| Unadjusted period prevalence (%) | |||
| Whole population | 5.41 | 6.23 | 4.29 |
| Only index persons | 6.41 | 7.31 | 5.06 |
| Median age at first event (years) | |||
| Whole population | 27.04 | 33.44 | 17.89 |
| Only index persons | 29.62 | 35.55 | 20.71 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 36160 | 25978 | 10182 |
| Unadjusted period prevalence (%) | 8.77 | 10.20 | 5.11 |
| Median age at first event (years) | 39.55 | 39.11 | 40.67 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint H7_CONJUNCTIVITIS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_CONJUNCTIVITIS | 0.866 [0.79, 0.95] | 0.002 |
| Birth year | 0.997 [0.99, 1.01] | 0.484 |
During the follow-up period (1.1.1998 — 31.12.2019), 10001 out of 164025 females with H7_CONJUNCTIVITIS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_CONJUNCTIVITIS | 1.011 [0.91, 1.12] | 0.829 |
| Birth year | 0.992 [0.98, 1.0] | 0.065 |
During the follow-up period (1.1.1998 — 31.12.2019), 6651 out of 115135 males with H7_CONJUNCTIVITIS died.
Mortality risk
Mortality risk for people of age
years, who have H7_CONJUNCTIVITIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.07% | 0.267% |
| 5 | 0.438% | 1.416% |
| 10 | 1.158% | 3.465% |
| 15 | 2.534% | 6.496% |
| 20 | 4.521% | 11.22% |
Relationships between endpoints
↥Index endpoint: H7_CONJUNCTIVITIS – Conjunctivitis
GWS hits: 13
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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