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Conjunctivitis (acute, non atopic)

DOID EFO Endpoint Browser PheWeb

H7_CONJUNCTIVITISACUNONATOPIC

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — H10|H13[1-2]
  • Hospital discharge: ICD-9 — 3720
  • Hospital discharge: ICD-8 — 360
  • Hospital discharge: excluded ICD-10 — H10.1, H10.4
  • Hospital discharge: excluded ICD-8 — 3600[1-2]
  • Cause of death: ICD-10 — H10|H13[1-2]
  • Cause of death: ICD-9 — 3720
  • Cause of death: ICD-8 — 360
  • Cause of death: excluded ICD-10 — H10.1, H10.4
  • Cause of death: excluded ICD-8 — 3600[1-2]

2 out of 7 registries used, show all original rules.

11810

4. Check minimum number of events

None

11810

5. Include endpoints

None

11810

6. Filter based on genotype QC (FinnGen only)

11295

Control definitions (FinnGen only)

Control exclude H7_CONJUNCTIVA

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 142138 74639 66949
Only index persons 112690 61353 51337
Unadjusted period prevalence (%)
Whole population 2.01 2.14 1.87
Only index persons 2.12 2.26 1.96
Median age at first event (years)
Whole population 27.03 32.04 21.34
Only index persons 35.21 38.48 31.29

-FinnGen-

Key figures

All Female Male
Number of individuals 11295 7121 4174
Unadjusted period prevalence (%) 2.54 2.80 2.10
Median age at first event (years) 47.39 45.57 50.51

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint H7_CONJUNCTIVITISACUNONATOPIC and mortality.

Females

Parameter HR [95% CI] p-value
H7_CONJUNCTIVITISACUNONATOPIC 1.131 [1.01, 1.26] 0.03
Birth year 0.995 [0.99, 1.0] 0.247

During the follow-up period (1.1.1998 — 31.12.2019), 4407 out of 65451 females with H7_CONJUNCTIVITISACUNONATOPIC died.

Males

Parameter HR [95% CI] p-value
H7_CONJUNCTIVITISACUNONATOPIC 1.287 [1.14, 1.46] < 0.001
Birth year 0.985 [0.98, 0.99] 0.002

During the follow-up period (1.1.1998 — 31.12.2019), 4130 out of 55068 males with H7_CONJUNCTIVITISACUNONATOPIC died.

Mortality risk

Mortality risk for people of age

years, who have H7_CONJUNCTIVITISACUNONATOPIC.

N-year risk Females Males
1 0.094% 0.239%
5 0.653% 1.454%
10 1.793% 3.503%
15 3.243% 6.781%
20 5.66% 11.287%

Relationships between endpoints

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Index endpoint: H7_CONJUNCTIVITISACUNONATOPIC – Conjunctivitis (acute, non atopic)

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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