allergic conjunctivitis: Conjunctivitis due to hypersensitivity to various allergens.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
27126 |
6. Filter based on genotype QC (FinnGen only) |
26125 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF2
Allergic conjunctivitis
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 239320 | 148884 | 89699 |
| Only index persons | 227459 | 143511 | 83948 |
| Unadjusted period prevalence (%) | |||
| Whole population | 3.59 | 4.26 | 2.51 |
| Only index persons | 4.51 | 5.28 | 3.20 |
| Median age at first event (years) | |||
| Whole population | 26.84 | 34.62 | 13.85 |
| Only index persons | 27.33 | 34.76 | 14.64 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 26125 | 19877 | 6248 |
| Unadjusted period prevalence (%) | 6.69 | 7.81 | 3.14 |
| Median age at first event (years) | 36.52 | 37.25 | 34.20 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint H7_ALLERGICCONJUNCTIVITIS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_ALLERGICCONJUNCTIVITIS | 0.723 [0.67, 0.78] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.053 |
During the follow-up period (1.1.1998 — 31.12.2019), 5773 out of 104020 females with H7_ALLERGICCONJUNCTIVITIS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_ALLERGICCONJUNCTIVITIS | 0.752 [0.68, 0.84] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.038 |
During the follow-up period (1.1.1998 — 31.12.2019), 2587 out of 62896 males with H7_ALLERGICCONJUNCTIVITIS died.
Mortality risk
Mortality risk for people of age
years, who have H7_ALLERGICCONJUNCTIVITIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.066% | 0.117% |
| 5 | 0.388% | 0.932% |
| 10 | 1.061% | 2.47% |
| 15 | 1.998% | 4.814% |
| 20 | 3.401% | 8.358% |
Relationships between endpoints
↥Index endpoint: H7_ALLERGICCONJUNCTIVITIS – Allergic conjunctivitis
GWS hits: 20
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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