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Migraine

DOID EFO Endpoint Browser PheWeb

G6_MIGRAINE

migraine disorder: A common, severe type of vascular headache often associated with increased sympathetic activity, resulting in nausea, vomiting, and light sensitivity.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — G43
  • Hospital discharge: ICD-9 — 346
  • Hospital discharge: ICD-8 — 346
  • Hospital discharge: excluded ICD-8 — 34601
  • Cause of death: ICD-10 — G43
  • Cause of death: ICD-9 — 346
  • Cause of death: ICD-8 — 346
  • Cause of death: excluded ICD-8 — 34601

2 out of 7 registries used, show all original rules.

24857

4. Check minimum number of events

None

24857

5. Include endpoints

24857

6. Filter based on genotype QC (FinnGen only)

23899

Control definitions (FinnGen only)

Control exclude G6_EPIPAROX

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 G40-G47
Name in latin Hemicrania

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 182609 133269 48268
Only index persons 174552 129263 45289
Unadjusted period prevalence (%)
Whole population 3.15 3.82 1.35
Only index persons 3.97 4.75 1.73
Median age at first event (years)
Whole population 32.88 35.07 26.80
Only index persons 33.09 35.03 27.55

-FinnGen-

Key figures

All Female Male
Number of individuals 23899 19745 4154
Unadjusted period prevalence (%) 6.77 7.75 2.09
Median age at first event (years) 39.54 38.99 42.14

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint G6_MIGRAINE and mortality.

Females

Parameter HR [95% CI] p-value
G6_MIGRAINE 0.853 [0.75, 0.96] 0.011
Birth year 0.999 [0.99, 1.01] 0.797

During the follow-up period (1.1.1998 — 31.12.2019), 2666 out of 103652 females with G6_MIGRAINE died.

Males

Parameter HR [95% CI] p-value
G6_MIGRAINE 0.927 [0.81, 1.06] 0.251
Birth year 0.984 [0.97, 0.99] 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 1355 out of 37239 males with G6_MIGRAINE died.

Mortality risk

Mortality risk for people of age

years, who have G6_MIGRAINE.

N-year risk Females Males
1 0.072% 0.125%
5 0.502% 0.919%
10 1.29% 2.33%
15 2.593% 4.442%
20 4.866% 7.636%

Relationships between endpoints

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Index endpoint: G6_MIGRAINE – Migraine

GWS hits: 4

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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