No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditions
|
51025 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
6180 |
6. Filter based on genotype QC (FinnGen only) |
5982 |
Control definitions (FinnGen only)
Control conditions
not MIGRAINE_TRIPTAN
Extra metadata
Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF5
Similar endpoints
↥List of similar endpoints to
Migraine with aura and triptan purchases
based on the number of shared cases.
Similar with more cases:
- Migraine with aura
- Migraine
- Migraine, single triptan purchase ok & required. ICD-code if available is included
- Triptan medication for migraine, single purchase ok
- Episodal and paroxysmal disorders
Similar with less cases:
None
Case counts by codes
↥FinnGen case counts by registry codes:
No data for upset plot.
No data for upset table.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 35643 | 29126 | 6331 |
| Only index persons | 35159 | 28910 | 6249 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.71 | 0.83 | 0.18 |
| Only index persons | 0.92 | 1.06 | 0.24 |
| Median age at first event (years) | |||
| Whole population | 34.01 | 34.46 | 31.90 |
| Only index persons | 34.02 | 34.46 | 31.98 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 5982 | 5290 | 692 |
| Unadjusted period prevalence (%) | 1.88 | 2.08 | 0.35 |
| Median age at first event (years) | 38.55 | 38.05 | 42.40 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint G6_MIGRAINE_WITH_AURA_TRIPTAN and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_MIGRAINE_WITH_AURA_TRIPTAN | 0.787 [0.67, 0.93] | 0.005 |
| Birth year | 1.002 [0.99, 1.01] | 0.724 |
During the follow-up period (1.1.1998 — 31.12.2019), 394 out of 23334 females with G6_MIGRAINE_WITH_AURA_TRIPTAN died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_MIGRAINE_WITH_AURA_TRIPTAN | 0.701 [0.57, 0.86] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.048 |
During the follow-up period (1.1.1998 — 31.12.2019), 130 out of 5128 males with G6_MIGRAINE_WITH_AURA_TRIPTAN died.
Mortality risk
Mortality risk for people of age
years, who have G6_MIGRAINE_WITH_AURA_TRIPTAN.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.072% | 0.134% |
| 5 | 0.522% | 0.822% |
| 10 | 1.411% | 2.244% |
| 15 | 2.884% | 4.423% |
| 20 | 5.216% | 7.404% |
Relationships between endpoints
↥Index endpoint: G6_MIGRAINE_WITH_AURA_TRIPTAN – Migraine with aura and triptan purchases
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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