migraine disorder: A common, severe type of vascular headache often associated with increased sympathetic activity, resulting in nausea, vomiting, and light sensitivity.
Migraine, single triptan purchase ok & required. ICD-code if available is included
DOID EFO Endpoint Browser PheWeb
MIGRAINE_TRIPTAN
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditions
|
51025 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
51025 |
6. Filter based on genotype QC (FinnGen only) |
49076 |
Control definitions (FinnGen only)
Control conditions
not TRIPTAN1
Extra metadata
First used in FinnGen datafreeze
DF3
Similar endpoints
↥List of similar endpoints to
Migraine, single triptan purchase ok & required. ICD-code if available is included
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No data for upset plot.
No data for upset table.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 389861 | 295751 | 91867 |
| Only index persons | 381814 | 291805 | 90009 |
| Unadjusted period prevalence (%) | |||
| Whole population | 7.04 | 8.47 | 2.57 |
| Only index persons | 9.01 | 10.73 | 3.44 |
| Median age at first event (years) | |||
| Whole population | 33.66 | 33.62 | 33.77 |
| Only index persons | 33.61 | 33.57 | 33.72 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 49076 | 40950 | 8126 |
| Unadjusted period prevalence (%) | 14.10 | 16.08 | 4.08 |
| Median age at first event (years) | 36.38 | 35.69 | 39.85 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint MIGRAINE_TRIPTAN and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| MIGRAINE_TRIPTAN | 0.751 [0.68, 0.83] | < 0.001 |
| Birth year | 0.998 [0.99, 1.01] | 0.514 |
During the follow-up period (1.1.1998 — 31.12.2019), 5277 out of 251401 females with MIGRAINE_TRIPTAN died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| MIGRAINE_TRIPTAN | 0.767 [0.69, 0.85] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.019 |
During the follow-up period (1.1.1998 — 31.12.2019), 2910 out of 79132 males with MIGRAINE_TRIPTAN died.
Mortality risk
Mortality risk for people of age
years, who have MIGRAINE_TRIPTAN.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.053% | 0.148% |
| 5 | 0.384% | 0.844% |
| 10 | 1.164% | 2.229% |
| 15 | 2.23% | 4.471% |
| 20 | 4.003% | 7.765% |
Relationships between endpoints
↥Index endpoint: MIGRAINE_TRIPTAN – Migraine, single triptan purchase ok & required. ICD-code if available is included
GWS hits: 43
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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