No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditions
|
51025 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
6720 |
6. Filter based on genotype QC (FinnGen only) |
6450 |
Control definitions (FinnGen only)
Control conditions
not MIGRAINE_TRIPTAN
Extra metadata
Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF5
Similar endpoints
↥List of similar endpoints to
Migraine without aura and triptan purchases
based on the number of shared cases.
Similar with more cases:
- Migraine without aura
- Migraine
- Migraine, single triptan purchase ok & required. ICD-code if available is included
- Triptan medication for migraine, single purchase ok
- Episodal and paroxysmal disorders
Similar with less cases:
None
Case counts by codes
↥FinnGen case counts by registry codes:
No data for upset plot.
No data for upset table.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 41331 | 32754 | 8348 |
| Only index persons | 40510 | 32409 | 8101 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.79 | 0.94 | 0.23 |
| Only index persons | 1.02 | 1.19 | 0.31 |
| Median age at first event (years) | |||
| Whole population | 32.38 | 33.96 | 26.11 |
| Only index persons | 32.51 | 34.00 | 26.55 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 6450 | 5714 | 736 |
| Unadjusted period prevalence (%) | 2.03 | 2.24 | 0.37 |
| Median age at first event (years) | 37.85 | 37.58 | 39.97 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint G6_MIGRAINE_NO_AURA_TRIPTAN and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_MIGRAINE_NO_AURA_TRIPTAN | 0.787 [0.68, 0.92] | 0.002 |
| Birth year | 1.001 [0.99, 1.01] | 0.778 |
During the follow-up period (1.1.1998 — 31.12.2019), 384 out of 26811 females with G6_MIGRAINE_NO_AURA_TRIPTAN died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_MIGRAINE_NO_AURA_TRIPTAN | 0.78 [0.65, 0.94] | 0.008 |
| Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 165 out of 7041 males with G6_MIGRAINE_NO_AURA_TRIPTAN died.
Mortality risk
Mortality risk for people of age
years, who have G6_MIGRAINE_NO_AURA_TRIPTAN.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.077% | 0.191% |
| 5 | 0.508% | 0.964% |
| 10 | 1.206% | 2.279% |
| 15 | 2.51% | 4.116% |
| 20 | 4.676% | 6.754% |
Relationships between endpoints
↥Index endpoint: G6_MIGRAINE_NO_AURA_TRIPTAN – Migraine without aura and triptan purchases
GWS hits: 4
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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