migraine without aura: A migraine disorder characterized by episodes that occur in the absence of preceding focal neurological symptoms.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
9016 |
4. Check minimum number of eventsNone |
9016 |
5. Include endpointsNone |
9016 |
6. Filter based on genotype QC (FinnGen only) |
8626 |
Control definitions (FinnGen only)
Control exclude
G6_EPIPAROX
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
G43
Name in latin
Hemicrania sine aura
Similar endpoints
↥List of similar endpoints to
Migraine without aura
based on the number of shared cases.
Similar with more cases:
- Migraine
- Episodal and paroxysmal disorders
- Neurological diseases
- Neurological diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 65091 | 46781 | 17966 |
| Only index persons | 62132 | 45519 | 16613 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.10 | 1.34 | 0.50 |
| Only index persons | 1.40 | 1.67 | 0.63 |
| Median age at first event (years) | |||
| Whole population | 28.61 | 32.80 | 17.56 |
| Only index persons | 29.50 | 33.13 | 19.57 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 8626 | 7352 | 1274 |
| Unadjusted period prevalence (%) | 2.56 | 2.89 | 0.64 |
| Median age at first event (years) | 37.87 | 37.77 | 38.41 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint G6_MIGRAINE_NO_AURA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_MIGRAINE_NO_AURA | 0.847 [0.73, 0.99] | 0.032 |
| Birth year | 0.997 [0.99, 1.01] | 0.648 |
During the follow-up period (1.1.1998 — 31.12.2019), 789 out of 38308 females with G6_MIGRAINE_NO_AURA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_MIGRAINE_NO_AURA | 0.952 [0.82, 1.11] | 0.536 |
| Birth year | 0.986 [0.98, 1.0] | 0.018 |
During the follow-up period (1.1.1998 — 31.12.2019), 439 out of 15066 males with G6_MIGRAINE_NO_AURA died.
Mortality risk
Mortality risk for people of age
years, who have G6_MIGRAINE_NO_AURA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.081% | 0.192% |
| 5 | 0.521% | 1.03% |
| 10 | 1.246% | 2.757% |
| 15 | 2.522% | 5.097% |
| 20 | 4.683% | 9.038% |
Relationships between endpoints
↥Index endpoint: G6_MIGRAINE_NO_AURA – Migraine without aura
GWS hits: 4
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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