migraine with aura: A migraine disorder characterized by episodes that are preceded by focal neurological symptoms.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
10723 |
4. Check minimum number of eventsNone |
10723 |
5. Include endpointsNone |
10723 |
6. Filter based on genotype QC (FinnGen only) |
10366 |
Control definitions (FinnGen only)
Control exclude
G6_EPIPAROX
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
G43
Name in latin
Hemicrania cum aura
Similar endpoints
↥List of similar endpoints to
Migraine with aura
based on the number of shared cases.
Similar with more cases:
- Migraine
- Episodal and paroxysmal disorders
- Neurological diseases
- Neurological diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 70820 | 53638 | 16847 |
| Only index persons | 69217 | 52835 | 16382 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.28 | 1.54 | 0.47 |
| Only index persons | 1.63 | 1.94 | 0.63 |
| Median age at first event (years) | |||
| Whole population | 35.29 | 35.91 | 33.30 |
| Only index persons | 35.42 | 35.96 | 33.66 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 10366 | 8630 | 1736 |
| Unadjusted period prevalence (%) | 2.97 | 3.39 | 0.87 |
| Median age at first event (years) | 41.98 | 40.81 | 47.77 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint G6_MIGRAINE_WITH_AURA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_MIGRAINE_WITH_AURA | 0.85 [0.73, 0.99] | 0.032 |
| Birth year | 0.989 [0.98, 1.0] | 0.019 |
During the follow-up period (1.1.1998 — 31.12.2019), 1040 out of 42574 females with G6_MIGRAINE_WITH_AURA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_MIGRAINE_WITH_AURA | 0.71 [0.61, 0.83] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.016 |
During the follow-up period (1.1.1998 — 31.12.2019), 461 out of 13340 males with G6_MIGRAINE_WITH_AURA died.
Mortality risk
Mortality risk for people of age
years, who have G6_MIGRAINE_WITH_AURA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.08% | 0.168% |
| 5 | 0.485% | 0.88% |
| 10 | 1.132% | 2.184% |
| 15 | 2.09% | 4.44% |
| 20 | 3.724% | 7.328% |
Relationships between endpoints
↥Index endpoint: G6_MIGRAINE_WITH_AURA – Migraine with aura
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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