No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
4853 |
4. Check minimum number of eventsNone |
4853 |
5. Include endpoints |
5247 |
6. Filter based on genotype QC (FinnGen only) |
4861 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2
Disorders of psychological development
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 145720 | 47114 | 98516 |
| Only index persons | 116461 | 38516 | 77945 |
| Unadjusted period prevalence (%) | |||
| Whole population | 2.30 | 1.35 | 2.75 |
| Only index persons | 2.46 | 1.42 | 2.98 |
| Median age at first event (years) | |||
| Whole population | 6.90 | 7.79 | 6.45 |
| Only index persons | 7.91 | 9.33 | 7.20 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 4861 | 2358 | 2503 |
| Unadjusted period prevalence (%) | 1.10 | 0.93 | 1.26 |
| Median age at first event (years) | 11.61 | 14.36 | 9.02 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint F5_PSYCHDEV and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_PSYCHDEV | 2.395 [1.83, 3.14] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.131 |
During the follow-up period (1.1.1998 — 31.12.2019), 734 out of 37554 females with F5_PSYCHDEV died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_PSYCHDEV | 2.288 [1.8, 2.91] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 1000 out of 80706 males with F5_PSYCHDEV died.
Mortality risk
Mortality risk for people of age
years, who have F5_PSYCHDEV.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.191% | 0.366% |
| 5 | 1.211% | 2.358% |
| 10 | 3.3% | 6.098% |
| 15 | 6.343% | 11.962% |
| 20 | 10.734% | 19.764% |
Relationships between endpoints
↥Index endpoint: F5_PSYCHDEV – Disorders of psychological development
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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