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Specific development disorders of scholastic skills

DOID EFO Endpoint Browser PheWeb

F5_SCHOLA

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — F81
  • Hospital discharge: ICD-9 — 315[0-2]
  • Hospital discharge: ICD-8 — 3061
  • Cause of death: ICD-10 — F81
  • Cause of death: ICD-9 — 315[0-2]
  • Cause of death: ICD-8 — 3061

2 out of 7 registries used, show all original rules.

1619

4. Check minimum number of events

None

1619

5. Include endpoints

1619

6. Filter based on genotype QC (FinnGen only)

1512

Control definitions (FinnGen only)

Control exclude F5_PSYCHDEV

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF9
Parent code in ICD-10 F80-F89
Name in latin Perturbationes specificae progressionis facultatis discendi

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 40733 14544 26158
Only index persons 37350 13430 23920
Unadjusted period prevalence (%)
Whole population 0.62 0.42 0.73
Only index persons 0.76 0.49 0.91
Median age at first event (years)
Whole population 11.19 12.15 10.64
Only index persons 11.61 12.64 11.03

-FinnGen-

Key figures

All Female Male
Number of individuals 1512 792 720
Unadjusted period prevalence (%) 0.34 0.31 0.36
Median age at first event (years) 13.72 15.14 12.14

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint F5_SCHOLA and mortality.

Females

Parameter HR [95% CI] p-value
F5_SCHOLA 2.413 [1.84, 3.16] < 0.001
Birth year 0.989 [0.98, 1.0] 0.013

During the follow-up period (1.1.1998 — 31.12.2019), 94 out of 11747 females with F5_SCHOLA died.

Males

Parameter HR [95% CI] p-value
F5_SCHOLA 1.657 [1.4, 1.97] < 0.001
Birth year 0.991 [0.98, 1.0] 0.064

During the follow-up period (1.1.1998 — 31.12.2019), 252 out of 21835 males with F5_SCHOLA died.

Mortality risk

Mortality risk for people of age

years, who have F5_SCHOLA.

N-year risk Females Males
1 0.186% 0.348%
5 1.052% 2.127%
10 2.88% 5.474%
15 5.112% 10.542%
20 9.327% 17.257%

Relationships between endpoints

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Index endpoint: F5_SCHOLA – Specific development disorders of scholastic skills

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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