No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
|
1. Apply sex-specific ruleNone |
- |
2. Check conditionsNone |
|
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
- |
4. Check minimum number of eventsNone |
- |
5. Include endpointsNone |
- |
6. Filter based on genotype QC (FinnGen only)None |
- |
Control definitions (FinnGen only)
Control exclude
KRA_PSY_ANYMENTAL
Extra metadata
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Speech and linguistic disorders
based on the number of shared cases.
Similar with more cases:
- Speech and linguistic disorders
- Disorders of psychological development
- Any mental disorder
- Psychiatric diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No upset plot: script not run.
No upset table: script not run.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 97743 | 31956 | 65733 |
| Only index persons | 79113 | 26544 | 52569 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.53 | 0.92 | 1.84 |
| Only index persons | 1.66 | 0.98 | 2.01 |
| Median age at first event (years) | |||
| Whole population | 6.89 | 7.95 | 6.36 |
| Only index persons | 7.77 | 9.26 | 7.02 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 3310 | 1639 | 1671 |
| Unadjusted period prevalence (%) | 0.74 | 0.64 | 0.84 |
| Median age at first event (years) | 11.00 | 13.49 | 8.56 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint KRA_PSY_SPEELING_EXMORE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| KRA_PSY_SPEELING_EXMORE | 2.338 [1.67, 3.27] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.296 |
During the follow-up period (1.1.1998 — 31.12.2019), 543 out of 25674 females with KRA_PSY_SPEELING_EXMORE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| KRA_PSY_SPEELING_EXMORE | 1.602 [1.17, 2.19] | 0.003 |
| Birth year | 0.988 [0.98, 1.0] | 0.015 |
During the follow-up period (1.1.1998 — 31.12.2019), 657 out of 53651 males with KRA_PSY_SPEELING_EXMORE died.
Mortality risk
Mortality risk for people of age
years, who have KRA_PSY_SPEELING_EXMORE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.289% | 0.307% |
| 5 | 1.414% | 2.018% |
| 10 | 3.314% | 4.768% |
| 15 | 6.522% | 8.937% |
| 20 | 11.442% | 14.904% |
Relationships between endpoints
↥Index endpoint: KRA_PSY_SPEELING_EXMORE – Speech and linguistic disorders
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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