No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
801 |
4. Check minimum number of eventsNone |
801 |
5. Include endpointsNone |
801 |
6. Filter based on genotype QC (FinnGen only) |
724 |
Control definitions (FinnGen only)
Control exclude
F5_PSYCHDEV
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
F80-F89
Name in latin
Perturbationes progressus specificae mixtae
Similar endpoints
↥List of similar endpoints to
Mixed specific developmental disorders
based on the number of shared cases.
Similar with more cases:
- Disorders of psychological development
- Any mental disorder
- Psychiatric diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 32334 | 9898 | 22428 |
| Only index persons | 24048 | 7389 | 16659 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.52 | 0.28 | 0.63 |
| Only index persons | 0.52 | 0.27 | 0.64 |
| Median age at first event (years) | |||
| Whole population | 5.94 | 6.11 | 5.86 |
| Only index persons | 6.45 | 6.68 | 6.35 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 724 | 309 | 415 |
| Unadjusted period prevalence (%) | 0.17 | 0.12 | 0.21 |
| Median age at first event (years) | 6.57 | 7.32 | 6.01 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint F5_MIXEDDEV and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_MIXEDDEV | 3.661 [2.58, 5.2] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.032 |
During the follow-up period (1.1.1998 — 31.12.2019), 54 out of 8685 females with F5_MIXEDDEV died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_MIXEDDEV | 2.156 [1.77, 2.62] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 146 out of 19887 males with F5_MIXEDDEV died.
Mortality risk
Mortality risk for people of age
years, who have F5_MIXEDDEV.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.259% | 0.317% |
| 5 | 1.439% | 2.249% |
| 10 | 4.139% | 6.384% |
| 15 | 8.235% | 11.432% |
| 20 | 14.601% | 18.666% |
Relationships between endpoints
↥Index endpoint: F5_MIXEDDEV – Mixed specific developmental disorders
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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