No definition available.
COPD related to chronic (opportunist) infections
EFO MESH Endpoint Browser PheWeb
COPD_OPPORTUNIST_INFECTIONS
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditions
|
21285 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
724 |
6. Filter based on genotype QC (FinnGen only) |
702 |
Control definitions (FinnGen only)
Control conditions
not J10_COPDNAS
Extra metadata
First used in FinnGen datafreeze
DF3
Similar endpoints
↥List of similar endpoints to
COPD related to chronic (opportunist) infections
based on the number of shared cases.
Similar with more cases:
- COPD, early/later onset
- Other chronic obstructive pulmonary disease
- COPD
- Other chronic obstructive pulmonary disease , including avohilmo
- Chronic lower respiratory diseases
Similar with less cases:
None
Case counts by codes
↥FinnGen case counts by registry codes:
No data for upset plot.
No data for upset table.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 5779 | 2148 | 3513 |
| Only index persons | 4088 | 1704 | 2384 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.09 | 0.06 | 0.10 |
| Only index persons | 0.08 | 0.06 | 0.09 |
| Median age at first event (years) | |||
| Whole population | 66.31 | 65.05 | 67.09 |
| Only index persons | 66.29 | 65.07 | 67.17 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 702 | 237 | 465 |
| Unadjusted period prevalence (%) | 0.19 | 0.09 | 0.23 |
| Median age at first event (years) | 67.05 | 61.96 | 69.65 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint COPD_OPPORTUNIST_INFECTIONS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| COPD_OPPORTUNIST_INFECTIONS | 2.652 [2.3, 3.05] | < 0.001 |
| Birth year | 1.0 [0.99, 1.01] | 0.953 |
During the follow-up period (1.1.1998 — 31.12.2019), 633 out of 1389 females with COPD_OPPORTUNIST_INFECTIONS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| COPD_OPPORTUNIST_INFECTIONS | 2.541 [2.21, 2.92] | < 0.001 |
| Birth year | 0.982 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 1245 out of 2143 males with COPD_OPPORTUNIST_INFECTIONS died.
Mortality risk
Mortality risk for people of age
years, who have COPD_OPPORTUNIST_INFECTIONS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.272% | 0.412% |
| 5 | 1.622% | 2.284% |
| 10 | 4.163% | 5.977% |
| 15 | 8.101% | 11.142% |
| 20 | 14.53% | 18.826% |
Relationships between endpoints
↥Index endpoint: COPD_OPPORTUNIST_INFECTIONS – COPD related to chronic (opportunist) infections
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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