cutaneous melanoma: A primary melanoma arising from atypical melanocytes in the skin. Precursor lesions include acquired and congenital melanocytic nevi, and dysplastic nevi. Several histologic variants have been recognized, including superficial spreading melanoma, acral lentiginous melanoma, nodular melanoma, and lentigo maligna melanoma.
Benign neoplasm of middle ear and respiratory system
DOID EFO Endpoint Browser PheWeb
CD2_BENIGN_EAR_RESP
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
2409 |
4. Check minimum number of eventsNone |
2409 |
5. Include endpoints |
2832 |
6. Filter based on genotype QC (FinnGen only) |
2736 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D10-D36
Name in latin
Neoplasma benignum auris mediae sive systematis respiratorii
Similar endpoints
↥List of similar endpoints to
Benign neoplasm of middle ear and respiratory system
based on the number of shared cases.
Similar with more cases:
- Benign neoplasm of middle ear and respiratory system
- Benign neoplasms
- Benign neoplasms
- Neoplasms
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 20664 | 8807 | 11667 |
| Only index persons | 17527 | 7830 | 9697 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.29 | 0.25 | 0.33 |
| Only index persons | 0.33 | 0.29 | 0.37 |
| Median age at first event (years) | |||
| Whole population | 55.29 | 55.15 | 55.31 |
| Only index persons | 53.78 | 53.91 | 53.68 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2736 | 1137 | 1599 |
| Unadjusted period prevalence (%) | 0.65 | 0.45 | 0.80 |
| Median age at first event (years) | 56.33 | 52.95 | 58.73 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint CD2_BENIGN_EAR_RESP and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_BENIGN_EAR_RESP | 1.387 [1.24, 1.55] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.056 |
During the follow-up period (1.1.1998 — 31.12.2019), 1065 out of 5721 females with CD2_BENIGN_EAR_RESP died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_BENIGN_EAR_RESP | 1.589 [1.44, 1.76] | < 0.001 |
| Birth year | 0.984 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 1926 out of 7557 males with CD2_BENIGN_EAR_RESP died.
Mortality risk
Mortality risk for people of age
years, who have CD2_BENIGN_EAR_RESP.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.112% | 0.271% |
| 5 | 0.805% | 1.641% |
| 10 | 1.946% | 4.303% |
| 15 | 3.24% | 7.829% |
| 20 | 5.823% | 12.915% |
Relationships between endpoints
↥Index endpoint: CD2_BENIGN_EAR_RESP – Benign neoplasm of middle ear and respiratory system
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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