Benign neoplasm: Respiratory system, unspecified

CD2_BENIGN_RESPIRATORY_NOS

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D14.4&
  • Hospital discharge: ICD-8 21299
  • Cause of death: ICD-10 D14.4&
  • Cause of death: ICD-8 21299

2 out of 7 registries used, show all original rules.

68

4. Check minimum number of events

None

68

5. Include endpoints

None

68

6. Filter based on genotype QC (FinnGen only)

63

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 D14
Name in latin Neoplasma benignum organi respiratorii non specificati

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 588 308 276
Only index persons 477 253 224
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 53.81 51.97 55.67
Only index persons 51.51 50.21 52.97

-FinnGen-

Key figures

All Female Male
Number of individuals 63 32 31
Unadjusted period prevalence (%) 0.01 0.01 0.02
Median age at first event (years) 53.98 48.23 59.92

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

Association

Association between endpoint CD2_BENIGN_RESPIRATORY_NOS and mortality.

Females

No data

Males

Parameter HR [95% CI] p-value
CD2_BENIGN_RESPIRATORY_NOS 1.947 [1.32, 2.87] < 0.001
Birth year 0.987 [0.98, 1.0] 0.006

During the follow-up period (1.1.1998 — 31.12.2019), 58 out of 183 males with CD2_BENIGN_RESPIRATORY_NOS died.

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_RESPIRATORY_NOS.

N-year risk Females Males
1 No data 0.295%
5 No data 2.14%
10 No data 5.616%
15 No data 10.662%
20 No data 17.775%

Relationships between endpoints

Index endpoint: CD2_BENIGN_RESPIRATORY_NOS – Benign neoplasm: Respiratory system, unspecified

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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