No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
|
1. Apply sex-specific ruleNone |
- |
2. Check conditionsNone |
|
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
- |
4. Check minimum number of eventsNone |
- |
5. Include endpointsNone |
- |
6. Filter based on genotype QC (FinnGen only)None |
- |
Control definitions (FinnGen only)
Control exclude
C3_CANCER, C3_CANCER_WIDE
Extra metadata
Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF9
Similar endpoints
↥List of similar endpoints to
Colorectal adenocarcinoma
based on the number of shared cases.
Similar with more cases:
- Colorectal adenocarcinoma
- Colorectal cancer
- Colorectal cancer
- Malignant neoplasm of digestive organs
- Malignant neoplasm of digestive organs
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No upset plot: script not run.
No upset table: script not run.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 69475 | 32225 | 35877 |
| Only index persons | 44191 | 21288 | 22903 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.97 | 0.92 | 1.00 |
| Only index persons | 0.83 | 0.78 | 0.87 |
| Median age at first event (years) | |||
| Whole population | 70.09 | 70.94 | 69.37 |
| Only index persons | 70.38 | 71.08 | 69.73 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 7284 | 2933 | 4351 |
| Unadjusted period prevalence (%) | 1.77 | 1.15 | 2.19 |
| Median age at first event (years) | 69.01 | 67.84 | 69.80 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint C3_COLORECTAL_ADENO_EXALLC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| C3_COLORECTAL_ADENO_EXALLC | 2.419 [2.21, 2.65] | < 0.001 |
| Birth year | 1.0 [0.99, 1.01] | 0.98 |
During the follow-up period (1.1.1998 — 31.12.2019), 10632 out of 20901 females with C3_COLORECTAL_ADENO_EXALLC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| C3_COLORECTAL_ADENO_EXALLC | 2.353 [2.11, 2.62] | < 0.001 |
| Birth year | 0.982 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 12638 out of 23453 males with C3_COLORECTAL_ADENO_EXALLC died.
Mortality risk
Mortality risk for people of age
years, who have C3_COLORECTAL_ADENO_EXALLC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.208% | 0.475% |
| 5 | 1.494% | 2.462% |
| 10 | 3.201% | 6.003% |
| 15 | 6.989% | 10.737% |
| 20 | 12.481% | 18.055% |
Relationships between endpoints
↥Index endpoint: C3_COLORECTAL_ADENO_EXALLC – Colorectal adenocarcinoma
GWS hits: 16
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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