No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
3307 |
4. Check minimum number of eventsNone |
3307 |
5. Include endpointsNone |
3307 |
6. Filter based on genotype QC (FinnGen only) |
3194 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
First used in FinnGen datafreeze
DF8
Similar endpoints
↥List of similar endpoints to
Adenocarcinoma and papilloma adenocarcinoma of rectum
based on the number of shared cases.
Similar with more cases:
- Adenocarcinoma and papilloma adenacarcinoma of rectum
- Adenocarcinoma, papilloma adenocarcinoma and mucinous carcinomas of rectum
- Adenocarcinoma, papilloma adenocarcinoma and mucinous carcinomas of rectum
- Colorectal adenocarcinoma
- Colorectal adenocarcinoma
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 28800 | 11906 | 16255 |
| Only index persons | 17730 | 7604 | 10126 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.41 | 0.34 | 0.45 |
| Only index persons | 0.34 | 0.28 | 0.39 |
| Median age at first event (years) | |||
| Whole population | 68.80 | 69.27 | 68.50 |
| Only index persons | 68.69 | 68.89 | 68.54 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 3194 | 1180 | 2014 |
| Unadjusted period prevalence (%) | 0.81 | 0.46 | 1.01 |
| Median age at first event (years) | 67.74 | 66.28 | 68.60 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint C3_RECTUM_ADENO and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| C3_RECTUM_ADENO | 2.736 [2.47, 3.04] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.147 |
During the follow-up period (1.1.1998 — 31.12.2019), 3757 out of 7528 females with C3_RECTUM_ADENO died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| C3_RECTUM_ADENO | 2.683 [2.41, 2.99] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.006 |
During the follow-up period (1.1.1998 — 31.12.2019), 5642 out of 10593 males with C3_RECTUM_ADENO died.
Mortality risk
Mortality risk for people of age
years, who have C3_RECTUM_ADENO.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.436% | 0.519% |
| 5 | 1.75% | 2.748% |
| 10 | 4.207% | 7.496% |
| 15 | 8.114% | 13.755% |
| 20 | 13.161% | 22.668% |
Relationships between endpoints
↥Index endpoint: C3_RECTUM_ADENO – Adenocarcinoma and papilloma adenocarcinoma of rectum
GWS hits: 5
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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