No definition available.
Adenocarcinoma, papilloma adenocarcinoma and mucinous carcinomas of rectum
C3_RECTUM_ADENO_MUCINO_EXALLC
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
|
1. Apply sex-specific ruleNone |
- |
2. Check conditionsNone |
|
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
- |
4. Check minimum number of eventsNone |
- |
5. Include endpointsNone |
- |
6. Filter based on genotype QC (FinnGen only)None |
- |
Control definitions (FinnGen only)
Control exclude
C3_CANCER, C3_CANCER_WIDE
Extra metadata
First used in FinnGen datafreeze
DF9
Name in latin
Carcinoma in situ cavitatis oris, oesophagi sive ventriculi
Similar endpoints
↥List of similar endpoints to
Adenocarcinoma, papilloma adenocarcinoma and mucinous carcinomas of rectum
based on the number of shared cases.
Similar with more cases:
- Adenocarcinoma, papilloma adenocarcinoma and mucinous carcinomas of rectum
- Colorectal cancer
- Colorectal cancer
- Malignant neoplasm of digestive organs
- Malignant neoplasm of digestive organs
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No upset plot: script not run.
No upset table: script not run.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 29932 | 12369 | 16907 |
| Only index persons | 18465 | 7909 | 10556 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.43 | 0.35 | 0.47 |
| Only index persons | 0.35 | 0.29 | 0.40 |
| Median age at first event (years) | |||
| Whole population | 68.81 | 69.29 | 68.51 |
| Only index persons | 68.75 | 68.95 | 68.59 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 3328 | 1219 | 2109 |
| Unadjusted period prevalence (%) | 0.85 | 0.48 | 1.06 |
| Median age at first event (years) | 67.79 | 66.27 | 68.67 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint C3_RECTUM_ADENO_MUCINO_EXALLC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| C3_RECTUM_ADENO_MUCINO_EXALLC | 2.762 [2.49, 3.06] | < 0.001 |
| Birth year | 0.998 [0.99, 1.01] | 0.55 |
During the follow-up period (1.1.1998 — 31.12.2019), 3911 out of 7834 females with C3_RECTUM_ADENO_MUCINO_EXALLC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| C3_RECTUM_ADENO_MUCINO_EXALLC | 2.602 [2.34, 2.9] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.006 |
During the follow-up period (1.1.1998 — 31.12.2019), 5907 out of 11064 males with C3_RECTUM_ADENO_MUCINO_EXALLC died.
Mortality risk
Mortality risk for people of age
years, who have C3_RECTUM_ADENO_MUCINO_EXALLC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.245% | 0.514% |
| 5 | 1.755% | 3.076% |
| 10 | 4.155% | 7.711% |
| 15 | 8.079% | 14.07% |
| 20 | 14.21% | 22.463% |
Relationships between endpoints
↥Index endpoint: C3_RECTUM_ADENO_MUCINO_EXALLC – Adenocarcinoma, papilloma adenocarcinoma and mucinous carcinomas of rectum
GWS hits: 8
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data