No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
|
1. Apply sex-specific ruleNone |
- |
2. Check conditionsNone |
|
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
- |
4. Check minimum number of eventsNone |
- |
5. Include endpoints |
- |
6. Filter based on genotype QC (FinnGen only)None |
- |
Control definitions (FinnGen only)
Control exclude
C3_CANCER, C3_CANCER_WIDE
Extra metadata
Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF4
Similar endpoints
↥List of similar endpoints to
Colorectal cancer
based on the number of shared cases.
Similar with more cases:
- Colorectal cancer
- Malignant neoplasm of digestive organs
- Malignant neoplasm of digestive organs
- Malignant neoplasm
- Malignant neoplasm
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No upset plot: script not run.
No upset table: script not run.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 85584 | 40710 | 43246 |
| Only index persons | 54628 | 27039 | 27589 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.20 | 1.17 | 1.21 |
| Only index persons | 1.02 | 0.99 | 1.05 |
| Median age at first event (years) | |||
| Whole population | 69.94 | 70.78 | 69.20 |
| Only index persons | 70.05 | 70.64 | 69.46 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 8801 | 3686 | 5115 |
| Unadjusted period prevalence (%) | 2.10 | 1.45 | 2.57 |
| Median age at first event (years) | 68.50 | 66.86 | 69.68 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint C3_COLORECTAL_EXALLC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| C3_COLORECTAL_EXALLC | 2.539 [2.3, 2.8] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.049 |
During the follow-up period (1.1.1998 — 31.12.2019), 12775 out of 25588 females with C3_COLORECTAL_EXALLC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| C3_COLORECTAL_EXALLC | 2.633 [2.36, 2.94] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 14751 out of 27619 males with C3_COLORECTAL_EXALLC died.
Mortality risk
Mortality risk for people of age
years, who have C3_COLORECTAL_EXALLC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.271% | 0.441% |
| 5 | 1.273% | 2.951% |
| 10 | 3.288% | 7.13% |
| 15 | 5.99% | 13.097% |
| 20 | 10.515% | 21.649% |
Relationships between endpoints
↥Index endpoint: C3_COLORECTAL_EXALLC – Colorectal cancer
GWS hits: 15
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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