No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
|
1. Apply sex-specific ruleNone |
- |
2. Check conditionsNone |
|
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
- |
4. Check minimum number of eventsNone |
- |
5. Include endpoints
|
- |
6. Filter based on genotype QC (FinnGen only)None |
- |
Control definitions (FinnGen only)
Control exclude
C3_CANCER, C3_CANCER_WIDE
Extra metadata
Level in the ICD hierarchy
1
First used in FinnGen datafreeze
DF9
Malignant neoplasm
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 839528 | 402694 | 422373 |
| Only index persons | 522509 | 273218 | 249291 |
| Unadjusted period prevalence (%) | |||
| Whole population | 11.73 | 11.53 | 11.80 |
| Only index persons | 9.79 | 10.04 | 9.52 |
| Median age at first event (years) | |||
| Whole population | 66.26 | 64.63 | 67.80 |
| Only index persons | 65.86 | 63.89 | 68.02 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 100190 | 48810 | 51380 |
| Unadjusted period prevalence (%) | 22.57 | 19.17 | 25.80 |
| Median age at first event (years) | 64.71 | 61.25 | 68.00 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint C3_CANCER_EXALLC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| C3_CANCER_EXALLC | 3.651 [3.36, 3.96] | < 0.001 |
| Birth year | 0.981 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 101188 out of 238234 females with C3_CANCER_EXALLC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| C3_CANCER_EXALLC | 3.332 [3.06, 3.63] | < 0.001 |
| Birth year | 0.977 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 129259 out of 246798 males with C3_CANCER_EXALLC died.
Mortality risk
Mortality risk for people of age
years, who have C3_CANCER_EXALLC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.158% | 0.286% |
| 5 | 1.042% | 1.803% |
| 10 | 2.483% | 4.343% |
| 15 | 4.573% | 8.046% |
| 20 | 7.833% | 13.311% |
Relationships between endpoints
↥Index endpoint: C3_CANCER_EXALLC – Malignant neoplasm
GWS hits: 54
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data