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Other malignant neoplasms of skin (=non-melanoma skin cancer)

Endpoint Browser PheWeb

C3_OTHER_SKIN_EXALLC

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

None

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2. Check conditions

  • not C3_MELANOMA_SKIN
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3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cause of death: ICD-10 — C44
  • Cause of death: ICD-9 — 173
  • Cause of death: ICD-8 — 173
  • Cancer registry: Topography ICD-O-3 — C44
  • Cancer registry: Morphology ICD-O-3 — ANY
  • Cancer registry: Behaviour codes — 3

2 out of 7 registries used, show all original rules.

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4. Check minimum number of events

None

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5. Include endpoints

None

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6. Filter based on genotype QC (FinnGen only)

None

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Control definitions (FinnGen only)

Control exclude C3_CANCER, C3_CANCER_WIDE
Control conditions not C3_MELANOMA_SKIN

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF9

Case counts by codes

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FinnGen case counts by registry codes:

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Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 37470 17663 19389
Only index persons 28807 14018 14789
Unadjusted period prevalence (%)
Whole population 0.52 0.51 0.54
Only index persons 0.54 0.52 0.56
Median age at first event (years)
Whole population 77.33 79.11 75.78
Only index persons 77.57 79.14 76.10

-FinnGen-

Key figures

All Female Male
Number of individuals 23503 11148 12355
Unadjusted period prevalence (%) 5.34 4.38 6.20
Median age at first event (years) 68.42 67.02 69.69

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint C3_OTHER_SKIN_EXALLC and mortality.

Females

Parameter HR [95% CI] p-value
C3_OTHER_SKIN_EXALLC 1.238 [1.11, 1.39] < 0.001
Birth year 0.995 [0.99, 1.0] 0.206

During the follow-up period (1.1.1998 — 31.12.2019), 6210 out of 13211 females with C3_OTHER_SKIN_EXALLC died.

Males

Parameter HR [95% CI] p-value
C3_OTHER_SKIN_EXALLC 1.237 [1.1, 1.39] < 0.001
Birth year 0.99 [0.98, 1.0] 0.025

During the follow-up period (1.1.1998 — 31.12.2019), 6539 out of 14188 males with C3_OTHER_SKIN_EXALLC died.

Mortality risk

Mortality risk for people of age

years, who have C3_OTHER_SKIN_EXALLC.

N-year risk Females Males
1 0.128% 0.29%
5 0.754% 1.579%
10 1.912% 4.011%
15 3.531% 7.572%
20 5.975% 12.481%

Relationships between endpoints

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Index endpoint: C3_OTHER_SKIN_EXALLC – Other malignant neoplasms of skin (=non-melanoma skin cancer)

GWS hits: 70

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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