No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
|
1. Apply sex-specific ruleNone |
- |
2. Check conditionsNone |
|
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
- |
4. Check minimum number of eventsNone |
- |
5. Include endpoints |
- |
6. Filter based on genotype QC (FinnGen only)None |
- |
Control definitions (FinnGen only)
Control exclude
C3_CANCER, C3_CANCER_WIDE
Extra metadata
Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF4
Similar endpoints
↥List of similar endpoints to
Malignant neoplasm of skin
based on the number of shared cases.
Similar with more cases:
- Malignant neoplasm of skin
- Malignant neoplasm
- Malignant neoplasm
- Any event in cancer register
- Malignant neoplasm, wide definition for exclusion
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No upset plot: script not run.
No upset table: script not run.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 72285 | 34368 | 37107 |
| Only index persons | 56752 | 28095 | 28657 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.01 | 0.98 | 1.04 |
| Only index persons | 1.06 | 1.03 | 1.09 |
| Median age at first event (years) | |||
| Whole population | 70.99 | 71.38 | 70.66 |
| Only index persons | 70.68 | 70.50 | 70.85 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 27435 | 13043 | 14392 |
| Unadjusted period prevalence (%) | 6.23 | 5.12 | 7.23 |
| Median age at first event (years) | 67.59 | 65.86 | 69.15 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint C3_SKIN_EXALLC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| C3_SKIN_EXALLC | 1.302 [1.17, 1.45] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.326 |
During the follow-up period (1.1.1998 — 31.12.2019), 8907 out of 24745 females with C3_SKIN_EXALLC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| C3_SKIN_EXALLC | 1.496 [1.34, 1.68] | < 0.001 |
| Birth year | 0.983 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 10566 out of 26597 males with C3_SKIN_EXALLC died.
Mortality risk
Mortality risk for people of age
years, who have C3_SKIN_EXALLC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.132% | 0.263% |
| 5 | 0.811% | 1.384% |
| 10 | 1.906% | 3.585% |
| 15 | 3.73% | 6.989% |
| 20 | 6.589% | 11.66% |
Relationships between endpoints
↥Index endpoint: C3_SKIN_EXALLC – Malignant neoplasm of skin
GWS hits: 82
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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