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Malignant melanoma of skin

Endpoint Browser PheWeb

C3_MELANOMA_SKIN_EXALLC

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

None

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2. Check conditions

None

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cause of death: ICD-10 — C43
  • Cause of death: ICD-9 — 172
  • Cause of death: ICD-8 — 172
  • Cancer registry: Topography ICD-O-3 — C44
  • Cancer registry: Morphology ICD-O-3 — 8720|8721|8726|8730|8742|8743|8744|8745
  • Cancer registry: Behaviour codes — 3

2 out of 7 registries used, show all original rules.

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4. Check minimum number of events

None

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5. Include endpoints

None

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6. Filter based on genotype QC (FinnGen only)

None

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Control definitions (FinnGen only)

Control exclude C3_CANCER, C3_CANCER_WIDE

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF9

Case counts by codes

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FinnGen case counts by registry codes:

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Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 34815 16705 17718
Only index persons 27945 14077 13868
Unadjusted period prevalence (%)
Whole population 0.49 0.48 0.50
Only index persons 0.52 0.52 0.53
Median age at first event (years)
Whole population 61.69 60.06 63.21
Only index persons 61.38 59.26 63.54

-FinnGen-

Key figures

All Female Male
Number of individuals 3932 1895 2037
Unadjusted period prevalence (%) 0.89 0.74 1.02
Median age at first event (years) 61.60 57.67 65.26

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint C3_MELANOMA_SKIN_EXALLC and mortality.

Females

Parameter HR [95% CI] p-value
C3_MELANOMA_SKIN_EXALLC 1.583 [1.42, 1.77] < 0.001
Birth year 0.993 [0.98, 1.0] 0.099

During the follow-up period (1.1.1998 — 31.12.2019), 2697 out of 11534 females with C3_MELANOMA_SKIN_EXALLC died.

Males

Parameter HR [95% CI] p-value
C3_MELANOMA_SKIN_EXALLC 1.738 [1.55, 1.95] < 0.001
Birth year 0.985 [0.98, 0.99] 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 4027 out of 12409 males with C3_MELANOMA_SKIN_EXALLC died.

Mortality risk

Mortality risk for people of age

years, who have C3_MELANOMA_SKIN_EXALLC.

N-year risk Females Males
1 0.105% 0.402%
5 0.91% 2.108%
10 2.145% 4.887%
15 4.168% 8.944%
20 7.348% 14.474%

Relationships between endpoints

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Index endpoint: C3_MELANOMA_SKIN_EXALLC – Malignant melanoma of skin

GWS hits: 11

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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