No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
|
1. Apply sex-specific ruleNone |
- |
2. Check conditionsNone |
|
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
4 out of 7 registries used, show all original rules. |
- |
4. Check minimum number of eventsNone |
- |
5. Include endpoints |
- |
6. Filter based on genotype QC (FinnGen only)None |
- |
Control definitions (FinnGen only)
Control exclude
C3_CANCER, C3_CANCER_WIDE
Extra metadata
Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF9
Malignant melanoma
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 43044 | 21308 | 21302 |
| Only index persons | 35457 | 18316 | 17141 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.60 | 0.61 | 0.60 |
| Only index persons | 0.66 | 0.67 | 0.65 |
| Median age at first event (years) | |||
| Whole population | 63.08 | 61.97 | 64.19 |
| Only index persons | 62.92 | 61.47 | 64.47 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 5122 | 2515 | 2607 |
| Unadjusted period prevalence (%) | 1.15 | 0.99 | 1.31 |
| Median age at first event (years) | 63.11 | 59.90 | 66.21 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint C3_MELANOMA_EXALLC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| C3_MELANOMA_EXALLC | 1.46 [1.32, 1.61] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.185 |
During the follow-up period (1.1.1998 — 31.12.2019), 3760 out of 15422 females with C3_MELANOMA_EXALLC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| C3_MELANOMA_EXALLC | 1.551 [1.39, 1.73] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.012 |
During the follow-up period (1.1.1998 — 31.12.2019), 4933 out of 15384 males with C3_MELANOMA_EXALLC died.
Mortality risk
Mortality risk for people of age
years, who have C3_MELANOMA_EXALLC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.156% | 0.289% |
| 5 | 0.94% | 1.857% |
| 10 | 2.244% | 4.49% |
| 15 | 4.224% | 8.412% |
| 20 | 7.32% | 14.376% |
Relationships between endpoints
↥Index endpoint: C3_MELANOMA_EXALLC – Malignant melanoma
GWS hits: 12
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data