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Malignant neoplasm of colon

Endpoint Browser PheWeb

C3_COLON_EXALLC

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

None

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2. Check conditions

None

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cause of death: ICD-10 — C18
  • Cause of death: ICD-9 — 153
  • Cause of death: ICD-8 — 153
  • Cancer registry: Topography ICD-O-3 — C18
  • Cancer registry: Morphology ICD-O-3 — ANY
  • Cancer registry: Behaviour codes — 3

2 out of 7 registries used, show all original rules.

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4. Check minimum number of events

None

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5. Include endpoints

None

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6. Filter based on genotype QC (FinnGen only)

None

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Control definitions (FinnGen only)

Control exclude C3_CANCER, C3_CANCER_WIDE

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF9

Case counts by codes

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FinnGen case counts by registry codes:

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Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 53884 27395 25534
Only index persons 35116 18489 16627
Unadjusted period prevalence (%)
Whole population 0.75 0.78 0.71
Only index persons 0.66 0.68 0.63
Median age at first event (years)
Whole population 70.84 71.77 69.90
Only index persons 71.06 71.78 70.26

-FinnGen-

Key figures

All Female Male
Number of individuals 5284 2361 2923
Unadjusted period prevalence (%) 1.23 0.93 1.47
Median age at first event (years) 69.29 67.81 70.49

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint C3_COLON_EXALLC and mortality.

Females

Parameter HR [95% CI] p-value
C3_COLON_EXALLC 2.489 [2.26, 2.74] < 0.001
Birth year 0.992 [0.98, 1.0] 0.042

During the follow-up period (1.1.1998 — 31.12.2019), 8659 out of 17191 females with C3_COLON_EXALLC died.

Males

Parameter HR [95% CI] p-value
C3_COLON_EXALLC 2.416 [2.16, 2.7] < 0.001
Birth year 0.988 [0.98, 1.0] 0.009

During the follow-up period (1.1.1998 — 31.12.2019), 8555 out of 16063 males with C3_COLON_EXALLC died.

Mortality risk

Mortality risk for people of age

years, who have C3_COLON_EXALLC.

N-year risk Females Males
1 0.157% 0.419%
5 1.248% 2.528%
10 3.192% 6.529%
15 5.896% 12.603%
20 10.336% 21.563%

Relationships between endpoints

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Index endpoint: C3_COLON_EXALLC – Malignant neoplasm of colon

GWS hits: 4

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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