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Colon adenocarcinoma

Endpoint Browser PheWeb

C3_COLON_ADENO_EXALLC

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

None

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2. Check conditions

  • HLP_C3_COLON_ADENO
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3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cause of death: ICD-10 — C18
  • Cause of death: ICD-9 — 153
  • Cause of death: ICD-8 — 153
  • Cancer registry: Topography ICD-O-3 — C18
  • Cancer registry: Morphology ICD-O-3 — 8140
  • Cancer registry: Behaviour codes — 3

2 out of 7 registries used, show all original rules.

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4. Check minimum number of events

None

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5. Include endpoints

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6. Filter based on genotype QC (FinnGen only)

None

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Control definitions (FinnGen only)

Control exclude C3_CANCER, C3_CANCER_WIDE
Control conditions not HLP_C3_COLON_ADENO

Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF8

Case counts by codes

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FinnGen case counts by registry codes:

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Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 41152 20539 19870
Only index persons 26808 13833 12975
Unadjusted period prevalence (%)
Whole population 0.58 0.59 0.56
Only index persons 0.50 0.51 0.50
Median age at first event (years)
Whole population 71.10 72.00 70.23
Only index persons 71.57 72.35 70.74

-FinnGen-

Key figures

All Female Male
Number of individuals 4147 1773 2374
Unadjusted period prevalence (%) 0.98 0.70 1.19
Median age at first event (years) 70.09 69.15 70.80

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint C3_COLON_ADENO_EXALLC and mortality.

Females

Parameter HR [95% CI] p-value
C3_COLON_ADENO_EXALLC 2.231 [2.03, 2.45] < 0.001
Birth year 0.997 [0.99, 1.0] 0.443

During the follow-up period (1.1.1998 — 31.12.2019), 6982 out of 13541 females with C3_COLON_ADENO_EXALLC died.

Males

Parameter HR [95% CI] p-value
C3_COLON_ADENO_EXALLC 2.312 [2.07, 2.58] < 0.001
Birth year 0.986 [0.98, 1.0] 0.003

During the follow-up period (1.1.1998 — 31.12.2019), 7082 out of 13041 males with C3_COLON_ADENO_EXALLC died.

Mortality risk

Mortality risk for people of age

years, who have C3_COLON_ADENO_EXALLC.

N-year risk Females Males
1 0.267% 0.424%
5 1.313% 2.622%
10 3.203% 5.848%
15 6.476% 11.21%
20 11.828% 18.824%

Relationships between endpoints

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Index endpoint: C3_COLON_ADENO_EXALLC – Colon adenocarcinoma

GWS hits: 5

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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