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Implicit Sepsis

AB1_SEPSIS_IMPLICIT

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

  • AB1_SEPSIS_CONDITION
50125

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 A0[0-9]|A19|A2[0-8]|A3[0-2]|A3[6-9]|A4[2-9]|A54|A59|A690|A691|A699|A70|A7[4-9]|A8[0-1]|A8[3-9]|A9[2-9]|B0[0-6]|B0[89]|B2[5-7]|B3[34]|B3[7-9]|B4[0-6]|B4[89]|B50|B5[45]|B5[7-9]|B60|B64|B67|B9[5-7]|B99|G0[0-8]|H050|H602|H700|I00|I33|I3[89]|I400|R02|J0[1-9]|J1[0-8]|J2[0-2]|J36|J39[01]|J8[56]|K3[567]|K57|K61|K63[01]|K65|K750|K810|K812|K830|L0[2-4]|L08|M0[01]|M86|N10|N151|N30|N390|N41[023]|N45|N7[0-4]|N980|O030|O035|O045|O080|O23|O753|O86|O883|O91|O98|T802|T814|T826|T827|T835|T836|T845|T846[0246]|T847|T857|T880|U04
  • Hospital discharge: ICD-9 00[1-9]|018|02[0-7]|03[0-6]|039|04[0-1]|04[5-9]|05[0-7]|06[0-6]|3483X|4275A|4589X|5185A|570|5722A|580|584|7800A|7802X|7855A|7855X|7991A|07[2-5]|0770A|0779X|07[89]|08[0-6]|088|098|10[01]|1049X|112|11[4-8]|122|13[0-1]|136|320|32[2-5]|3760A|3801C|3830A|390|421|4249X|46[1-6]|475|4782[AB]|48[0-5]|487|510|513|54[0-2]|562|56[67]|5695A|5698A|5720A|5750A|5751A|5761|590|595|5990|6010A|6012A|6013A|604|614|615|616|6342A|6351|6391A|6466A|647|6593B|670|672|6733|675|68[0-3]|686|711|730|7854A|7907A|7908A|9966A|9985A|9993A
  • Hospital discharge: excluded ICD-10 A021|A217|A227|A241|A282|A327|A427|A548|B007|B377
  • Hospital discharge: excluded ICD-9 0031A|0223A|0545A|1125A
  • Cause of death: ICD-10 A0[0-9]|A19|A2[0-8]|A3[0-2]|A3[6-9]|A4[2-9]|A54|A59|A690|A691|A699|A70|A7[4-9]|A8[0-1]|A8[3-9]|A9[2-9]|B0[0-6]|B0[89]|B2[5-7]|B3[34]|B3[7-9]|B4[0-6]|B4[89]|B50|B5[45]|B5[7-9]|B60|B64|B67|B9[5-7]|B99|G0[0-8]|H050|H602|H700|I00|I33|I3[89]|I400|R02|J0[1-9]|J1[0-8]|J2[0-2]|J36|J39[01]|J8[56]|K3[567]|K57|K61|K63[01]|K65|K750|K810|K812|K830|L0[2-4]|L08|M0[01]|M86|N10|N151|N30|N390|N41[023]|N45|N7[0-4]|N980|O030|O035|O045|O080|O23|O753|O86|O883|O91|O98|T802|T814|T826|T827|T835|T836|T845|T846[0246]|T847|T857|T880|U04
  • Cause of death: ICD-9 00[1-9]|018|02[0-7]|03[0-6]|039|04[0-1]|04[5-9]|05[0-7]|06[0-6]|3483X|4275A|4589X|5185A|570|5722A|580|584|7800A|7802X|7855A|7855X|7991A|07[2-5]|0770A|0779X|07[89]|08[0-6]|088|098|10[01]|1049X|112|11[4-8]|122|13[0-1]|136|320|32[2-5]|3760A|3801C|3830A|390|421|4249X|46[1-6]|475|4782[AB]|48[0-5]|487|510|513|54[0-2]|562|56[67]|5695A|5698A|5720A|5750A|5751A|5761|590|595|5990|6010A|6012A|6013A|604|614|615|616|6342A|6351|6391A|6466A|647|6593B|670|672|6733|675|68[0-3]|686|711|730|7854A|7907A|7908A|9966A|9985A|9993A
  • Cause of death: excluded ICD-10 A021|A217|A227|A241|A282|A327|A427|A548|B007|B377
  • Cause of death: excluded ICD-9 0031A|0223A|0545A|1125A

2 out of 7 registries used, show all original rules.

38082

4. Check minimum number of events

None

38082

5. Include endpoints

None

38082

6. Filter based on genotype QC (FinnGen only)

36652

Control definitions (FinnGen only)

Control exclude AB1_SEPSIS_EXPLICIT

Extra metadata

First used in FinnGen datafreeze DF8

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 36652 16871 19781
Unadjusted period prevalence (%) 8.41 6.63 9.93
Median age at first event (years) 60.50 56.66 63.78

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: AB1_SEPSIS_IMPLICIT – Implicit Sepsis

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).