Risteys · AB1_SEPSIS

Endpoint definition

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Endpoint definition steps	FinnGen
Phenotype data	473681
1. Apply sex-specific rule None	473681
2. Check conditions AB1_SEPSIS_CONDITION	50125
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — A0[0-9]\|A19\|A2[0-8]\|A3[0-2]\|A3[6-9]\|A4[2-9]\|A54\|A59\|A690\|A691\|A699\|A70\|A7[4-9]\|A8[0-1]\|A8[3-9]\|A9[2-9]\|B0[0-6]\|B0[89]\|B2[5-7]\|B3[34]\|B3[7-9]\|B4[0-6]\|B4[89]\|B50\|B5[45]\|B5[7-9]\|B60\|B64\|B67\|B9[5-7]\|B99\|G0[0-8]\|H050\|H602\|H700\|I00\|I33\|I3[89]\|I400\|R02\|J0[1-9]\|J1[0-8]\|J2[0-2]\|J36\|J39[01]\|J8[56]\|K3[567]\|K57\|K61\|K63[01]\|K65\|K750\|K810\|K812\|K830\|L0[2-4]\|L08\|M0[01]\|M86\|N10\|N151\|N30\|N390\|N41[023]\|N45\|N7[0-4]\|N980\|O030\|O035\|O045\|O080\|O23\|O753\|O86\|O883\|O91\|O98\|T802\|T814\|T826\|T827\|T835\|T836\|T845\|T846[0246]\|T847\|T857\|T880\|U04 Hospital discharge: ICD-9 — 00[1-9]\|018\|02[0-7]\|03[0-6]\|039\|04[0-1]\|04[5-9]\|05[0-7]\|06[0-6]\|3483X\|4275A\|4589X\|5185A\|570\|5722A\|580\|584\|7800A\|7802X\|7855A\|7855X\|7991A\|07[2-5]\|0770A\|0779X\|07[89]\|08[0-6]\|088\|098\|10[01]\|1049X\|112\|11[4-8]\|122\|13[0-1]\|136\|320\|32[2-5]\|3760A\|3801C\|3830A\|390\|421\|4249X\|46[1-6]\|475\|4782[AB]\|48[0-5]\|487\|510\|513\|54[0-2]\|562\|56[67]\|5695A\|5698A\|5720A\|5750A\|5751A\|5761\|590\|595\|5990\|6010A\|6012A\|6013A\|604\|614\|615\|616\|6342A\|6351\|6391A\|6466A\|647\|6593B\|670\|672\|6733\|675\|68[0-3]\|686\|711\|730\|7854A\|7907A\|7908A\|9966A\|9985A\|9993A Hospital discharge: excluded ICD-10 — A021\|A217\|A227\|A241\|A282\|A327\|A427\|A548\|B007\|B377 Hospital discharge: excluded ICD-9 — 0031A\|0223A\|0545A\|1125A Cause of death: ICD-10 — A0[0-9]\|A19\|A2[0-8]\|A3[0-2]\|A3[6-9]\|A4[2-9]\|A54\|A59\|A690\|A691\|A699\|A70\|A7[4-9]\|A8[0-1]\|A8[3-9]\|A9[2-9]\|B0[0-6]\|B0[89]\|B2[5-7]\|B3[34]\|B3[7-9]\|B4[0-6]\|B4[89]\|B50\|B5[45]\|B5[7-9]\|B60\|B64\|B67\|B9[5-7]\|B99\|G0[0-8]\|H050\|H602\|H700\|I00\|I33\|I3[89]\|I400\|R02\|J0[1-9]\|J1[0-8]\|J2[0-2]\|J36\|J39[01]\|J8[56]\|K3[567]\|K57\|K61\|K63[01]\|K65\|K750\|K810\|K812\|K830\|L0[2-4]\|L08\|M0[01]\|M86\|N10\|N151\|N30\|N390\|N41[023]\|N45\|N7[0-4]\|N980\|O030\|O035\|O045\|O080\|O23\|O753\|O86\|O883\|O91\|O98\|T802\|T814\|T826\|T827\|T835\|T836\|T845\|T846[0246]\|T847\|T857\|T880\|U04 Cause of death: ICD-9 — 00[1-9]\|018\|02[0-7]\|03[0-6]\|039\|04[0-1]\|04[5-9]\|05[0-7]\|06[0-6]\|3483X\|4275A\|4589X\|5185A\|570\|5722A\|580\|584\|7800A\|7802X\|7855A\|7855X\|7991A\|07[2-5]\|0770A\|0779X\|07[89]\|08[0-6]\|088\|098\|10[01]\|1049X\|112\|11[4-8]\|122\|13[0-1]\|136\|320\|32[2-5]\|3760A\|3801C\|3830A\|390\|421\|4249X\|46[1-6]\|475\|4782[AB]\|48[0-5]\|487\|510\|513\|54[0-2]\|562\|56[67]\|5695A\|5698A\|5720A\|5750A\|5751A\|5761\|590\|595\|5990\|6010A\|6012A\|6013A\|604\|614\|615\|616\|6342A\|6351\|6391A\|6466A\|647\|6593B\|670\|672\|6733\|675\|68[0-3]\|686\|711\|730\|7854A\|7907A\|7908A\|9966A\|9985A\|9993A Cause of death: excluded ICD-10 — A021\|A217\|A227\|A241\|A282\|A327\|A427\|A548\|B007\|B377 Cause of death: excluded ICD-9 — 0031A\|0223A\|0545A\|1125A 2 out of 7 registries used, show all original rules.	38082
4. Check minimum number of events None	38082
5. Include endpoints None	38082
6. Filter based on genotype QC (FinnGen only)	36652

Control definitions (FinnGen only)

Control exclude AB1_SEPSIS_EXPLICIT

Extra metadata

First used in FinnGen datafreeze DF8

NAME	AB1_SEPSIS_IMPLICIT
CONTROL_EXCLUDE	AB1_SEPSIS_EXPLICIT
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS	AB1_SEPSIS_CONDITION
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	A0[0-9]\|A19\|A2[0-8]\|A3[0-2]\|A3[6-9]\|A4[2-9]\|A54\|A59\|A690\|A691\|A699\|A70\|A7[4-9]\|A8[0-1]\|A8[3-9]\|A9[2-9]\|B0[0-6]\|B0[89]\|B2[5-7]\|B3[34]\|B3[7-9]\|B4[0-6]\|B4[89]\|B50\|B5[45]\|B5[7-9]\|B60\|B64\|B67\|B9[5-7]\|B99\|G0[0-8]\|H050\|H602\|H700\|I00\|I33\|I3[89]\|I400\|R02\|J0[1-9]\|J1[0-8]\|J2[0-2]\|J36\|J39[01]\|J8[56]\|K3[567]\|K57\|K61\|K63[01]\|K65\|K750\|K810\|K812\|K830\|L0[2-4]\|L08\|M0[01]\|M86\|N10\|N151\|N30\|N390\|N41[023]\|N45\|N7[0-4]\|N980\|O030\|O035\|O045\|O080\|O23\|O753\|O86\|O883\|O91\|O98\|T802\|T814\|T826\|T827\|T835\|T836\|T845\|T846[0246]\|T847\|T857\|T880\|U04
HD_ICD_9	00[1-9]\|018\|02[0-7]\|03[0-6]\|039\|04[0-1]\|04[5-9]\|05[0-7]\|06[0-6]\|3483X\|4275A\|4589X\|5185A\|570\|5722A\|580\|584\|7800A\|7802X\|7855A\|7855X\|7991A\|07[2-5]\|0770A\|0779X\|07[89]\|08[0-6]\|088\|098\|10[01]\|1049X\|112\|11[4-8]\|122\|13[0-1]\|136\|320\|32[2-5]\|3760A\|3801C\|3830A\|390\|421\|4249X\|46[1-6]\|475\|4782[AB]\|48[0-5]\|487\|510\|513\|54[0-2]\|562\|56[67]\|5695A\|5698A\|5720A\|5750A\|5751A\|5761\|590\|595\|5990\|6010A\|6012A\|6013A\|604\|614\|615\|616\|6342A\|6351\|6391A\|6466A\|647\|6593B\|670\|672\|6733\|675\|68[0-3]\|686\|711\|730\|7854A\|7907A\|7908A\|9966A\|9985A\|9993A
HD_ICD_8
HD_ICD_10_EXCL	A021\|A217\|A227\|A241\|A282\|A327\|A427\|A548\|B007\|B377
HD_ICD_9_EXCL	0031A\|0223A\|0545A\|1125A
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	A0[0-9]\|A19\|A2[0-8]\|A3[0-2]\|A3[6-9]\|A4[2-9]\|A54\|A59\|A690\|A691\|A699\|A70\|A7[4-9]\|A8[0-1]\|A8[3-9]\|A9[2-9]\|B0[0-6]\|B0[89]\|B2[5-7]\|B3[34]\|B3[7-9]\|B4[0-6]\|B4[89]\|B50\|B5[45]\|B5[7-9]\|B60\|B64\|B67\|B9[5-7]\|B99\|G0[0-8]\|H050\|H602\|H700\|I00\|I33\|I3[89]\|I400\|R02\|J0[1-9]\|J1[0-8]\|J2[0-2]\|J36\|J39[01]\|J8[56]\|K3[567]\|K57\|K61\|K63[01]\|K65\|K750\|K810\|K812\|K830\|L0[2-4]\|L08\|M0[01]\|M86\|N10\|N151\|N30\|N390\|N41[023]\|N45\|N7[0-4]\|N980\|O030\|O035\|O045\|O080\|O23\|O753\|O86\|O883\|O91\|O98\|T802\|T814\|T826\|T827\|T835\|T836\|T845\|T846[0246]\|T847\|T857\|T880\|U04
COD_ICD_9	00[1-9]\|018\|02[0-7]\|03[0-6]\|039\|04[0-1]\|04[5-9]\|05[0-7]\|06[0-6]\|3483X\|4275A\|4589X\|5185A\|570\|5722A\|580\|584\|7800A\|7802X\|7855A\|7855X\|7991A\|07[2-5]\|0770A\|0779X\|07[89]\|08[0-6]\|088\|098\|10[01]\|1049X\|112\|11[4-8]\|122\|13[0-1]\|136\|320\|32[2-5]\|3760A\|3801C\|3830A\|390\|421\|4249X\|46[1-6]\|475\|4782[AB]\|48[0-5]\|487\|510\|513\|54[0-2]\|562\|56[67]\|5695A\|5698A\|5720A\|5750A\|5751A\|5761\|590\|595\|5990\|6010A\|6012A\|6013A\|604\|614\|615\|616\|6342A\|6351\|6391A\|6466A\|647\|6593B\|670\|672\|6733\|675\|68[0-3]\|686\|711\|730\|7854A\|7907A\|7908A\|9966A\|9985A\|9993A
COD_ICD_8
COD_ICD_10_EXCL	A021\|A217\|A227\|A241\|A282\|A327\|A427\|A548\|B007\|B377
COD_ICD_9_EXCL	0031A\|0223A\|0545A\|1125A
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

	All	Female	Male
Number of individuals	36652	16871	19781
Unadjusted period prevalence (%)	8.41	6.63	9.93
Median age at first event (years)	60.50	56.66	63.78

≡ Risteys

FG R11 + FR

FinnGen R10 + FinRegistry

FinnGen R10

FinnGen R9

FinnGen R8

FinnGen R7

FinnGen R6

FinnGen R5

FinnGen R4

FinnGen R3

Implicit Sepsis

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

All original rules

Similar endpoints

Case counts by codes

Upset plot

Case counts by code for Implicit Sepsis (AB1_SEPSIS_IMPLICIT)

Summary Statistics

-FinRegistry-

-FinnGen-

Key figures

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Relationships between endpoints