Protozoal diseases

AB1_PROTOZOAL

toxoplasmosis: A parasitic disease contracted by the ingestion or fetal transmission of toxoplasma gondii.

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 B50-B64
  • Hospital discharge: ICD-9 08[4-6]|130|136[3-4]|0889
  • Hospital discharge: ICD-8 08[6-7]|130|084|13601
  • Cause of death: ICD-10 B50-B64
  • Cause of death: ICD-9 08[4-6]|130|136[3-4]|0889
  • Cause of death: ICD-8 08[6-7]|130|084|13601

2 out of 7 registries used, show all original rules.

-

4. Check minimum number of events

None

-

5. Include endpoints

830

6. Filter based on genotype QC (FinnGen only)

795

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 6426 2933 3386
Only index persons 5431 2564 2867
Unadjusted period prevalence (%)
Whole population 0.09 0.08 0.09
Only index persons 0.10 0.09 0.11
Median age at first event (years)
Whole population 46.07 44.91 47.33
Only index persons 44.50 43.08 45.77

-FinnGen-

Key figures

All Female Male
Number of individuals 795 407 388
Unadjusted period prevalence (%) 0.18 0.16 0.19
Median age at first event (years) 55.62 51.23 60.23

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint AB1_PROTOZOAL and mortality.

Females

Parameter HR [95% CI] p-value
AB1_PROTOZOAL 3.997 [3.21, 4.98] < 0.001
Birth year 0.994 [0.99, 1.0] 0.171

During the follow-up period (1.1.1998 — 31.12.2019), 470 out of 1914 females with AB1_PROTOZOAL died.

Males

Parameter HR [95% CI] p-value
AB1_PROTOZOAL 3.555 [2.88, 4.38] < 0.001
Birth year 0.981 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 575 out of 2159 males with AB1_PROTOZOAL died.

Mortality risk

Mortality risk for people of age

years, who have AB1_PROTOZOAL.

N-year risk Females Males
1 0.377% 0.561%
5 2.125% 3.161%
10 5.209% 8.234%
15 9.94% 14.814%
20 17.521% 24.247%

Relationships between endpoints

Index endpoint: AB1_PROTOZOAL – Protozoal diseases

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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