toxoplasmosis: A parasitic disease contracted by the ingestion or fetal transmission of toxoplasma gondii.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
- |
4. Check minimum number of eventsNone |
- |
5. Include endpoints |
830 |
6. Filter based on genotype QC (FinnGen only) |
795 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2
Protozoal diseases
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 6426 | 2933 | 3386 |
| Only index persons | 5431 | 2564 | 2867 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.09 | 0.08 | 0.09 |
| Only index persons | 0.10 | 0.09 | 0.11 |
| Median age at first event (years) | |||
| Whole population | 46.07 | 44.91 | 47.33 |
| Only index persons | 44.50 | 43.08 | 45.77 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 795 | 407 | 388 |
| Unadjusted period prevalence (%) | 0.18 | 0.16 | 0.19 |
| Median age at first event (years) | 55.62 | 51.23 | 60.23 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint AB1_PROTOZOAL and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| AB1_PROTOZOAL | 3.997 [3.21, 4.98] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.171 |
During the follow-up period (1.1.1998 — 31.12.2019), 470 out of 1914 females with AB1_PROTOZOAL died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| AB1_PROTOZOAL | 3.555 [2.88, 4.38] | < 0.001 |
| Birth year | 0.981 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 575 out of 2159 males with AB1_PROTOZOAL died.
Mortality risk
Mortality risk for people of age
years, who have AB1_PROTOZOAL.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.377% | 0.561% |
| 5 | 2.125% | 3.161% |
| 10 | 5.209% | 8.234% |
| 15 | 9.94% | 14.814% |
| 20 | 17.521% | 24.247% |
Relationships between endpoints
↥Index endpoint: AB1_PROTOZOAL – Protozoal diseases
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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